What's Happening?
Researchers in Japan have developed a novel bacterial therapy that targets tumors without relying on the immune system. The therapy, known as AUN, consists of two bacteria: Proteus mirabilis and Rhodopseudomonas palustris. Administered intravenously, these bacteria accumulate within tumors and induce selective intratumoral thrombosis and necrosis, effectively destroying the tumors. This approach has shown complete tumor remission in both immunocompetent and immunocompromised mice, offering a promising drug-free strategy for cancer therapy.
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Why It's Important?
The development of immune-independent bacterial therapy represents a significant advancement in cancer treatment, particularly for patients who are immunocompromised due to chemotherapy or radiation. By bypassing the need for a functioning immune system, this therapy could provide effective treatment options for a broader range of cancer patients. The approach also highlights the potential of using naturally occurring bacteria in cancer therapy, which could lead to safer and more controllable treatment methods.
What's Next?
The research team plans to launch a startup to further develop the AUN therapy and conduct clinical trials within the next six years. These trials will aim to evaluate the safety and efficacy of the therapy in human patients. Researchers will also address concerns related to potential drug resistance and infection risks associated with live bacteria, ensuring the therapy's safety and effectiveness.
Beyond the Headlines
The use of bacteria in cancer therapy raises ethical and regulatory considerations, particularly regarding the use of live organisms in treatment. Long-term studies will be necessary to assess the impact of bacterial therapy on overall health and the potential for unintended consequences. Public acceptance of bacterial-based treatments may vary, requiring education and engagement to ensure widespread adoption.
