UCLA Study Finds Temporary Reversal of Autism-like Brain Changes in Mice with Rapamycin
A study conducted by UCLA Health has discovered that short-term immunosuppressive therapy using the drug rapamycin can temporarily reverse autism-like brain changes in adult mice. The research, published in Nature Communications, indicates that inflammation during pregnancy can lead to autism-like symptoms in offspring, such as abnormal brain growth and heightened sensory sensitivity. The study found that a single dose of rapamycin improved brain signaling and behavior symptoms within two hours, although the effects were temporary. The drug's impact suggests new therapeutic targets for future treatments, focusing on the brain's functional circuitry rather than its physical structure. The study highlights the potential for the adult brain to adapt functionally, even when structural changes from early development persist.