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Broncos at 49ers: Predictions, picks and odds for NFL Week 4 game

Broncos at 49ers: Predictions, picks and odds for NFL Week 4 game

The San Francisco 49ers host the Denver Broncos at Levi's Stadium on Oct. 4 and USA TODAY's NFL experts have locked in their picks for the action.
Stockton RecordStockton Record
San Francisco 49ers elevate veteran WR Brandin Cooks to 53-man roster

San Francisco 49ers elevate veteran WR Brandin Cooks to 53-man roster

The 49ers elevated veteran wide receiver Brandin Cooks to their 53-man roster Thursday roster ahead of their matchup with the Denver Broncos.
SB NationSB Nation
Broncos defense bracing for tough matchup versus versatile 49ers offense

Broncos defense bracing for tough matchup versus versatile 49ers offense

The Denver Broncos will have a big challenge going up the well-coached and versatile offense of the San Francisco 49ers.
SB NationSB Nation
49ers in review: The offense is off to a historic start

49ers in review: The offense is off to a historic start

And we all know why the 49ers are off to this historic start
Niners WireNiners Wire
49ers GM: Injured star will 'make every attempt' to play vs. Broncos

49ers GM: Injured star will 'make every attempt' to play vs. Broncos

Mike Evans is dealing with a rib injury, but GM John Lynch doesn't think that will stop the veteran receiver from playing in Week 4.
Niners WireNiners Wire
WR Mike Evans among 5 starters to miss 49ers 1st Week 4 practice

WR Mike Evans among 5 starters to miss 49ers 1st Week 4 practice

The San Francisco 49ers list of players not participating to open Week 4 practice is long.
SB NationSB Nation
NFL picks and predictions: Broncos vs. 49ers and the rest of Week 4

NFL picks and predictions: Broncos vs. 49ers and the rest of Week 4

Mile High Report’s Christopher Hart predicts the straight-up winners for every Week 4 matchup of the 2026 season.
Niners WireNiners Wire
Kyle Shanahan offers a mixed bag of injury updates on 6 49ers

Kyle Shanahan offers a mixed bag of injury updates on 6 49ers

The San Francisco 49ers have several players on their 53-man roster dealing with injuries, and Kyle Shanahan had updates on a few of them.
Niners WireNiners Wire
49ers favored to beat resurgent Broncos in tight Week 4 match

49ers favored to beat resurgent Broncos in tight Week 4 match

Oddsmakers think the 49ers have a good chance to go 4-0 with a home game against the Broncos up next.
Niners WireNiners Wire
49ers PFF grades: Best, worst players from Week 3 win over Cardinals

49ers PFF grades: Best, worst players from Week 3 win over Cardinals

The San Francisco 49ers defeated the Arizona Cardinals on Sunday, moving to 3-0 in 2026. Here were their best and worst PFF grades from the contest.
Seahawks WireSeahawks Wire
Broncos bail Seahawks out by beating Rams 30-26

Broncos bail Seahawks out by beating Rams 30-26

If there was a silver lining, it's the fact the Rams also lost in Week 3.
SB NationSB Nation
Mykel Williams’ practice window set to be opened, 49ers get good news on veteran trio

Mykel Williams’ practice window set to be opened, 49ers get good news on veteran trio

Williams will be eligible to make his season debut in Week 5.