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High-Intensity Interval Training (HIIT) Proven Effective for Aerobic Fitness and Fat Loss, Requires Sensible Dosing

High-Intensity Interval Training (HIIT) Proven Effective for Aerobic Fitness and Fat Loss, Requires Sensible Dosing

High-Intensity Interval Training (HIIT) Proven Effective for Aerobic Fitness and Fat Loss, Requires Sensible Dosing

WHOOP Technology Enhances Sleep and Recovery Insights for Improved Fitness

WHOOP Technology Enhances Sleep and Recovery Insights for Improved Fitness

WHOOP Technology Enhances Sleep and Recovery Insights for Improved Fitness

F45 Training Integrates Reebok Smart Ring for Enhanced Challenge Program Recovery

F45 Training Integrates Reebok Smart Ring for Enhanced Challenge Program Recovery

F45 Training Integrates Reebok Smart Ring for Enhanced Challenge Program Recovery

Strength Training Shrinks Fat Cells Before Weight Loss, Study Suggests

Strength Training Shrinks Fat Cells Before Weight Loss, Study Suggests

Strength Training Shrinks Fat Cells Before Weight Loss, Study Suggests

Fitness Platforms for Trainers See Increased Demand for Online Coaching and Client Management Tools

Fitness Platforms for Trainers See Increased Demand for Online Coaching and Client Management Tools

Fitness Platforms for Trainers See Increased Demand for Online Coaching and Client Management Tools

Penn State Research Reveals Gut Bacteria and Liver Modify Food Molecules to Impact Body Function

Penn State Research Reveals Gut Bacteria and Liver Modify Food Molecules to Impact Body Function

A new study led by Penn State researchers has found that both the human liver and gut bacteria can modify molecules from food, influencing signaling pathways that activate or deactivate genes. Published in 'Communications Biology,' the study, conducted in humans and mice, specifically examined the dietary amino acid tryptophan. When gut bacteria break down tryptophan, they produce indole-3-acetic acid (IAA). Researchers discovered that gut bacteria and the liver can chemically attach glycine to IAA, forming IAA-glycine. While conjugation typically aids in eliminating metabolites, IAA-glycine was found to activate the aryl hydrocarbon (Ah) receptor, a protein that regulates gene activity and enhances gut immune function and intestinal barrier integrity. This finding challenges previous assumptions that conjugation reactions might block receptor activation.

REV'd Chicago Opens as Latina and LGBTQ+-Owned Inclusive Fitness Studio in River North

REV'd Chicago Opens as Latina and LGBTQ+-Owned Inclusive Fitness Studio in River North

REV'd Chicago Opens as Latina and LGBTQ+-Owned Inclusive Fitness Studio in River North

Adjustable Dumbbells Offer Versatility and Space-Saving Solutions for Home Gyms

Adjustable Dumbbells Offer Versatility and Space-Saving Solutions for Home Gyms

Adjustable Dumbbells Offer Versatility and Space-Saving Solutions for Home Gyms

Orangetheory Fitness Emphasizes Scientifically Designed Workout of the Day for Comprehensive Fitness

Orangetheory Fitness Emphasizes Scientifically Designed Workout of the Day for Comprehensive Fitness

Orangetheory Fitness Emphasizes Scientifically Designed Workout of the Day for Comprehensive Fitness

Fitness Trackers and Smartwatches Show Inaccuracies in Calorie Burn Tracking, Especially for Individuals with Higher Body Fat

Fitness Trackers and Smartwatches Show Inaccuracies in Calorie Burn Tracking, Especially for Individuals with Higher Body Fat

Fitness Trackers and Smartwatches Show Inaccuracies in Calorie Burn Tracking, Especially for Individuals with Higher Body Fat

Johns Hopkins Medicine Study Reveals Modest Weight Loss Benefits of Time-Restricted Eating for Adults with Obesity and Prediabetes

Johns Hopkins Medicine Study Reveals Modest Weight Loss Benefits of Time-Restricted Eating for Adults with Obesity and Prediabetes

A recent study conducted by Johns Hopkins Medicine has provided evidence that time-restricted eating (TRE), a form of intermittent fasting, can lead to modest weight loss in adults diagnosed with obesity and prediabetes, or those with diet-controlled type 2 diabetes. The study, led by Daisy Duan, M.D., an assistant professor of medicine, focused on participants who adhered to a consistent 8- to 10-hour daily eating window. This research aimed to determine if the health benefits associated with intermittent fasting are solely due to weight loss or if other biological mechanisms are at play. The 12-week study involved a cohort of adults, predominantly female and Black, aged 18–69 years. Participants were randomly assigned to either a 10-hour TRE schedule or a 16-hour usual eating pattern (UEP). All participants received a personalized, heart-healthy adapted Dietary Approaches to Stop Hypertension (DASH) diet, with caloric intake adjusted to maintain their starting weights. Meals were prepared and provided by...

Viking Therapeutics' VK2735 Shows Promising Weight Loss Maintenance in Clinical Trials

Viking Therapeutics' VK2735 Shows Promising Weight Loss Maintenance in Clinical Trials

Viking Therapeutics announced positive topline results for its injectable GLP-1/GIP dual agonist, VK2735, demonstrating significant weight loss and impressive maintenance of that weight loss in a Phase 1 clinical trial. After 21 weeks, participants receiving 17.5 mg of VK2735 experienced an average body weight reduction of 17.7%. Crucially, the study also evaluated various maintenance dosing options. Following a transition to every-other-week dosing for three months, up to 97% of the weight loss was maintained, compared to 61% for the placebo group. Monthly dosing maintained up to 90% of the weight loss. An exploratory control arm that continued weekly dosing showed a 21.7% weight loss, with Viking suggesting further weight loss could occur with longer-term weekly administration. The safety profile was favorable, with gastrointestinal-related adverse events during the 12-week maintenance period being comparable to placebo, and no moderate or severe nausea reported in the step-down regimens.