New Genome Assembly Method Enables Affordable Sequencing of Over 1,000 Human Genomes
A research team led by Professor Jian Yang at Westlake University has developed a cost-effective method for assembling over 1,000 human genomes. The study, published in Nature, introduces the pangenome-informed genome assembly (PIGA) method, which combines long and short-read sequencing to construct a comprehensive pangenome. This approach significantly reduces sequencing costs and provides a new pathway for large-scale genomic studies. The resulting pangenome includes 1,116 diploid genomes and identifies millions of genetic variants, offering a valuable resource for medical and population genetics research. 
