Metformin Shows Potential in Delaying HIV Rebound, Study Finds
Researchers at the Gladstone Institutes have discovered that metformin, a common diabetes medication, may help maintain HIV in a dormant state, potentially delaying or preventing the virus's rebound in some individuals. The study, published in Immunity, highlights that metformin can activate protective mechanisms within infected cells, keeping HIV inactive. This finding is significant as it offers a new avenue for managing HIV without continuous antiretroviral therapy (ART). The research involved analyzing blood samples from clinical trials where participants paused ART under medical supervision. The study identified that higher levels of certain immune cells and genes were linked to delayed viral rebound, suggesting that metformin could play a role in a 'block and lock' strategy to suppress HIV. 
