Stratified Medicine Advances in Oncology with Focus on Rare Cancers and Drug Repurposing
Stratified medicine, also known as precision medicine, is evolving to tailor disease prevention, diagnosis, and treatment based on an individual's genetic, protein, environmental, and lifestyle information. In oncology, a tumor budding-based grading system, proposed by the International Association for the Study of Lung Cancer (IASLC), is being utilized to stratify risk in patients with resected lung squamous cell carcinoma (SqCC). This system helps identify individuals who may benefit from adjuvant chemotherapy. Furthermore, recent advancements in precision oncology are enabling tumor-agnostic repurposing methods. These methods are crucial for identifying new therapeutic opportunities, particularly for rare and ultra-rare cancers, where traditional treatment options are often limited or non-existent. The approach involves leveraging existing genomic data from routine clinical care to find new uses for established drugs, moving beyond conventional 'on-target' approaches to explore 'off-target' vulnerabilit...
