Leucovorin Autism Treatment Faces Shortage Amid Surging Demand
A supportive care drug, leucovorin, which may help ease hyperactivity and improve speech and communication in children with autism, has become highly sought after, leading to a shortage. The drug, a reduced form of folate or vitamin B9, gained popularity after being promoted by the Trump administration and featured in a widely viewed news story. A study published in JAMA Network Open reported a 2,000% increase in leucovorin prescriptions over three years. Despite its popularity, leucovorin is not FDA-approved for autism spectrum disorder, although it is approved for cerebral folate deficiency. The increased demand has left doctors struggling to meet patient needs, with some parents resorting to over-the-counter folic acid, which experts warn may not be as effective and could potentially cause harm.