3D Bioprinting and Photoacoustic Microscopy Enhance Cancer Drug Testing
Recent advancements in precision medicine have been highlighted through the integration of 3D bioprinting and photoacoustic microscopy (PAM) to evaluate anti-cancer drug efficacy. This innovative approach involves creating bioprinted tumor-vessel models that mimic the human tumor microenvironment. The study utilizes a custom-made high-resolution PAM system to investigate the effects of anti-cancer drugs on these models. By employing a pulsed laser for excitation, the system provides enhanced imaging depth and resolution, allowing for detailed observation of angiogenic responses and drug effects. The research demonstrates that this platform can effectively simulate tumor-induced angiogenesis and assess the impact of drugs like temozolomide and sunitinib, both individually and in combination, on vascular growth and tumor progression. 
