Berkeley Lab Researchers Develop Advanced Microscope and AI for Biological Discovery
Researchers at Lawrence Berkeley National Laboratory (Berkeley Lab) and collaborating institutions have developed the Multimodal Optical Scope with Adaptive Imaging Correction (MOSAIC), a reconfigurable microscope that integrates over ten imaging techniques into a single compact instrument. This new technology, featured on the cover of Nature Methods, allows scientists to observe biological processes across various scales and compare imaging methods on the same sample. MOSAIC generates massive datasets, up to four terabytes per hour, which necessitates advanced computational tools for processing and analysis. To address this, Berkeley Lab developed PetaKit5D, an open-source software toolkit capable of handling MOSAIC's output in real-time, significantly reducing processing costs. Two MOSAIC instruments at UC Berkeley are currently operating continuously to collect five-dimensional data (three spatial dimensions, time, and molecular identity) to train a new state-of-the-art AI model. This initiative aims to... 
