New Procedure May Prevent Weight Regain After Stopping GLP-1 Medications
A new minimally invasive outpatient procedure, known as duodenal mucosal resurfacing, is showing promise in helping individuals maintain weight loss after discontinuing popular weight-loss medications like Ozempic and semaglutide. According to research presented at Digestive Disease Week 2026, about 70% of people who stop these medications regain much of the weight they lost, often within 18 months. The procedure involves using controlled heat to remove damaged tissue from the duodenum, encouraging the growth of healthier tissue. This process aims to provide a lasting metabolic reset, helping the body maintain weight loss without ongoing medication. The REMAIN-1 trial, which is testing this procedure, has shown that participants who underwent the treatment regained significantly less weight compared to those who received a sham procedure. 
