Belinda Wang Lab Identifies Large-Effect Risk Genes for Obsessive-Compulsive Disorder
The Belinda Wang Lab is actively researching the genetic underpinnings of obsessive-compulsive disorder (OCD) and Tourette disorder. Their work focuses on identifying large-effect risk genes associated with these conditions through rare variant genetics. The lab employs computational and functional genomic approaches to understand how these genetic risk factors converge. The primary goal is to dissect how specific risk genes and patient variants alter molecular and cellular functions, ultimately aiming to uncover the molecular and cellular mechanisms that contribute to OCD. This research is part of a broader effort to improve diagnostic and treatment strategies for these highly heritable and impairing neuropsychiatric disorders, whose underlying biology is still not well understood. The lab integrates statistical genetics, functional genomics, and systems biology to connect genetic risk to disease mechanisms. 
