RUNX1 and GCN5 Interaction in Keratinocytes Promotes T Cell Activation in Psoriasis
Research has identified that the transcription factor RUNX1 recruits the histone acetyltransferase GCN5 in keratinocytes, leading to the upregulation of ICOSLG, a ligand that promotes T cell activation in the psoriasis microenvironment. This interaction enhances the expression of ICOSLG, which is positively correlated with psoriasis severity. The study utilized single-cell RNA sequencing and immunohistochemical analysis to demonstrate the upregulation of ICOSLG and RUNX1 in psoriatic lesions. The findings suggest that the ICOSLG-ICOS signaling axis is a key pathway mediating interactions between keratinocytes and T cells, contributing to the inflammatory response in psoriasis. 
