Novel Cancer Treatment Shows Promise in Mice, Combining HIF Inhibitors with Immunotherapy
Researchers at Johns Hopkins University and the University of Maryland School of Pharmacy have developed new small molecule drugs that inhibit hypoxia-inducible factors 1 and 2 (HIF-1/2), which are key regulators of cancer progression. These drugs, when combined with immunotherapy, have shown the ability to completely eliminate various types of tumors in mice, including breast, colorectal, melanoma, and prostate cancers. The study suggests that these drugs could potentially be used to treat a wide range of cancers in humans by overcoming resistance to immune checkpoint blockade therapy.