Study Links Ketamine Treatment to Increased Morning Cortisol in Depressed Patients
A recent clinical trial has revealed that a single dose of ketamine can increase morning cortisol levels in patients suffering from major depression and suicidal thoughts. Published in the Journal of Affective Disorders, the study found that this hormonal increase persists for at least 24 hours post-treatment. The research aimed to explore the stress hormone system as a potential biomarker for ketamine's therapeutic effects. Cortisol, a hormone produced by the adrenal glands, helps manage stress and typically peaks in the morning. The study involved 80 adults with major depressive disorder, who were randomly assigned to receive either ketamine or midazolam. Saliva samples were collected to measure cortisol levels before and after treatment. Results showed a significant increase in morning cortisol levels in the ketamine group, suggesting a link between ketamine treatment and the body's stress response system. 
