University of Oklahoma Research Identifies Stress Response as Trigger for Heart Inflammation
New research from the University of Oklahoma has identified the body's stress response as a trigger for heart inflammation following a heart attack. The study, published in Nature Communications, reveals that neutrophils, a type of white blood cell, are mobilized not from the bone marrow as previously thought, but from reserves along blood vessel walls. This rapid mobilization is triggered by stress hormones like norepinephrine, which signal the neutrophils to detach and travel to the heart, causing inflammation. The research, led by Prabha Nagareddy, Ph.D., suggests that controlling this response could improve heart healing. In experiments with mice, the use of beta two blockers reduced the harmful surge of neutrophils, leading to better heart recovery.