Self-Assembling Polymers Enhance Gene Delivery Efficiency and Safety
Researchers from the University of Manchester and the University of Birmingham have developed a new method for delivering genetic material into cells using self-assembling polymer carriers. This technique improves the effectiveness and reduces the toxicity of gene delivery compared to existing methods. The process involves Polymerization-Induced Electrostatic Self-Assembly (PIESA), which forms polyplexes by binding positively charged polymers to negatively charged DNA or RNA. This method avoids the instability and toxicity issues associated with traditional post-assembly steps, offering a more reliable and scalable approach to non-viral gene delivery. 
