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WATCH: 49ers shock the Cardinals with trick play to strike first blood

WATCH: 49ers shock the Cardinals with trick play to strike first blood

The 49ers got onto the scoreboard first in an NFC West clash with the Cardinals via some trickery from their offense.
USA TodayUSA Today
49ers vs Cardinals asks a simple question: How big is the gap?

49ers vs Cardinals asks a simple question: How big is the gap?

The San Francisco 49ers host the Arizona Cardinals at Levi's Stadium on Sept. 27 and USA TODAY's NFL experts have locked in their picks against the spread for the action.
For the WinFor the Win
Mike Evans injury update: Is 49ers WR playing against Cardinals?

Mike Evans injury update: Is 49ers WR playing against Cardinals?

Here's what we know about the Mike Evans' status on Sunday against the Cardinals
Cardinals WireCardinals Wire
49ers injury report: Mike Evans questionable vs. Cardinals

49ers injury report: Mike Evans questionable vs. Cardinals

See which 49ers players won't play or might not play against the Cardinals in Week 3.
For the WinFor the Win
When is Nick Bosa coming back to the 49ers?

When is Nick Bosa coming back to the 49ers?

Here's what we know about when Nick Bosa might come back to the 49ers as he deals with a calf injury.
SB NationSB Nation
49ers numbers to know: The Cardinals have a long NFC West streak on the line

49ers numbers to know: The Cardinals have a long NFC West streak on the line

Plus, the lack of 49ers pass rush
Cardinals WireCardinals Wire
Cardinals injury report: Garrett Williams making return

Cardinals injury report: Garrett Williams making return

See which Cardinals won't play or might not play against the 49ers on Sunday.
Niners WireNiners Wire
49ers GM John Lynch gives update on Brandin Cooks could see the field

49ers GM John Lynch gives update on Brandin Cooks could see the field

Don't expect Brandin Cooks to suit up for the 49ers anytime soon despite him recently signing with the team.
SB NationSB Nation
Arizona Cardinals defense still dealing with some injuries ahead of matchup with Niners

Arizona Cardinals defense still dealing with some injuries ahead of matchup with Niners

Check in on the Friday Cardinals injury report.
Niners WireNiners Wire
George Kittle credits one key factor in 49ers' hot 2-0 start

George Kittle credits one key factor in 49ers' hot 2-0 start

The 49ers retained a lot of key offensive personnel that helped them cruise to a 2-0 record to start 2026.
Niners WireNiners Wire
49ers head coach, offensive star explain what new WR brings to SF

49ers head coach, offensive star explain what new WR brings to SF

Brandin Cooks already has a glowing endorsement from his head coach and running back.
SB NationSB Nation
Nick Bosa could miss Week 5 matchup versus Seahawks

Nick Bosa could miss Week 5 matchup versus Seahawks

The 49ers defense has been hit hard by injuries in 2026, and Bosa is now expected to miss several weeks.