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Inside St. Jude’s Fight Against Childhood Cancer—from Genome Mapping to Global Impact

Inside St. Jude’s Fight Against Childhood Cancer—from Genome Mapping to Global Impact

Jude Children's Research Hospital has been at the forefront of pediatric cancer research and treatment since its inception in 1962. Located in Memp...

How Ceramide Research Is Revolutionizing Treatments for Psoriasis and Eczema

How Ceramide Research Is Revolutionizing Treatments for Psoriasis and Eczema

Ceramides are essential components of the skin's outermost layer, the stratum corneum, where they play a critical role in maintaining skin health. ...

It’s Not Just One Source: Why Your Body Recycles 90% of Its Essential Ceramides

It’s Not Just One Source: Why Your Body Recycles 90% of Its Essential Ceramides

Ceramides are essential lipid molecules involved in various cellular functions, including signaling and maintaining cell membrane integrity. Unders...

Study on Lung Cancer Cells' Metabolism Offers Insights for Improved Immunotherapy

Study on Lung Cancer Cells' Metabolism Offers Insights for Improved Immunotherapy

Researchers at the University of Queensland have conducted a study on the metabolism of lung cancer cells, revealing that glucose uptake plays a critical role in determining the effectiveness of immunotherapy. The study, published in Nature Communications, used machine learning to analyze cell interactions in non-small cell lung carcinoma (NSCLC). The findings suggest that higher glucose uptake in cancer cells is associated with poorer outcomes. This research aims to develop targeted treatments to enhance immunotherapy effectiveness, moving towards precision medicine where treatments are tailored to individual tumor profiles.

George Coukos Appointed Director of Ludwig Laboratory for Cell Therapy, Advancing Cancer Immunotherapy

George Coukos Appointed Director of Ludwig Laboratory for Cell Therapy, Advancing Cancer Immunotherapy

The Ludwig Institute for Cancer Research has announced the establishment of the Ludwig Laboratory for Cell Therapy at Weill Cornell Medicine, led by Dr. George Coukos. Dr. Coukos, a renowned expert in tumor immunology and cellular immunotherapy, returns to the U.S. after a transformative tenure in Switzerland. His leadership is expected to advance the development of cellular-based cancer therapies, focusing on personalized treatments for various malignancies. The laboratory aims to enhance the specificity and potency of immune cells used in cancer treatment, addressing challenges like tumor heterogeneity and immunosuppressive environments.

Dr. Kara Leigh Roncin Featured in Forbes for Contributions to Pathology

Dr. Kara Leigh Roncin Featured in Forbes for Contributions to Pathology

Dr. Kara Leigh Roncin, a pathologist at CHI Health, has been featured in the December 2025/January 2026 issue of Forbes magazine. Dr. Roncin specializes in breast pathology and has been recognized for her professional achievements and industry expertise. She holds dual board certifications in anatomic and clinical pathology from the American Board of Pathology. Her career includes significant roles such as chairperson of the Commission on Cancer/Network Cancer Committee and pathology lead for the Network Cancer Committee and the Breast Health Professional Advisory Board. Dr. Roncin has also served on the Non-Small Cell Lung Carcinoma Biomarker Testing Learning Collaborative with the American Society of Clinical Pathology. Her educational background includes a Bachelor of Science in anatomy and cell biology from the University of Saskatchewan and a Doctor of Medicine from the Medical University of the Americas.

Researchers Develop Genetic Blueprint to Combat T Cell Exhaustion in Cancer Therapy

Researchers Develop Genetic Blueprint to Combat T Cell Exhaustion in Cancer Therapy

A multi-institutional study led by researchers from the UNC Lineberger Comprehensive Cancer Center, the Salk Institute for Biological Studies, and UC San Diego has identified new genetic mechanisms that influence the state of CD8+ killer T cells. These cells are crucial for immune defense, targeting virus-infected and cancer cells. However, they can become ineffective in chronic infections or tumors, entering a state known as T cell exhaustion. The study, published in Nature, outlines a detailed atlas of CD8+ T cell states, revealing how these cells transition from protective to dysfunctional states. By manipulating specific genetic switches, researchers found they could restore the tumor-killing function of T cells without compromising their long-term immune memory. This discovery has significant implications for improving immunotherapy and infectious disease research.

Chris Olsen, Brother of NFL Analyst Greg Olsen, Passes Away at 42 After Battling Brain Cancer

Chris Olsen, Brother of NFL Analyst Greg Olsen, Passes Away at 42 After Battling Brain Cancer

Chris Olsen, the brother of Fox NFL analyst Greg Olsen, has passed away at the age of 42 following a battle with glioblastoma, a highly aggressive form of brain cancer. Chris, who was two years older than Greg, was known for his vibrant spirit and love for life, which remained undiminished despite his illness. He was a former football player, having spent one year at Notre Dame before transferring to the University of Virginia, where he played in 13 games over three seasons. Chris was born in Paterson, New Jersey, and was a star quarterback at Wayne Hills High School under the coaching of his father, Chris Olsen Sr. He spent his later years in Little Rock, Arkansas, where he was surrounded by family and friends who came to share memories and celebrate his life.

Austin Butler Cast as Lance Armstrong in Upcoming Biopic by Edward Berger and Scott Stuber

Austin Butler Cast as Lance Armstrong in Upcoming Biopic by Edward Berger and Scott Stuber

Austin Butler Cast as Lance Armstrong in Upcoming Biopic by Edward Berger and Scott Stuber

New Deep Learning Model PARM Enhances Understanding of Gene Regulation

New Deep Learning Model PARM Enhances Understanding of Gene Regulation

A collaborative research effort led by scientists at the Netherlands Cancer Institute and Oncode Institute has resulted in the development of a deep learning model known as PARM (promoter activity regulatory model). This model provides new insights into the regulation of human promoters by transcription factors, which are crucial for understanding when genes are activated or deactivated. The PARM model is designed to predict the functional impact of regulatory mutations in specific cell types and conditions, such as drug treatments. This advancement is significant for cancer diagnostics, patient stratification, and future therapies. The model leverages a combination of lab experimentation and computation, utilizing massively parallel reporter assays (MPRAs) to measure gene regulation at an unprecedented scale. The research indicates that gene regulation is more predictable than previously thought, offering a new platform for understanding the dynamic regulation of human promoters.

Israeli Researchers Use AI to Uncover Herpesvirus Activation Mechanisms, Paving Way for New Treatments

Israeli Researchers Use AI to Uncover Herpesvirus Activation Mechanisms, Paving Way for New Treatments

Researchers at Bar-Ilan University in Israel have developed an artificial intelligence tool named ENHAvir, which has successfully identified genetic control switches that activate herpesviruses from a dormant state. This discovery is significant as it could lead to targeted treatments for diseases caused by herpesviruses, including certain types of cancer. The AI model, which operates similarly to search engines but focuses on genetic sequences, identified novel enhancers in various herpesviruses, such as Epstein-Barr virus and Cytomegalovirus. These findings are expected to guide future research into drug treatments and preventive measures for herpesvirus-related diseases.

Oregon Legislature Advances Bill to Eliminate Cervical Cancer Screening Costs

Oregon Legislature Advances Bill to Eliminate Cervical Cancer Screening Costs

The Oregon Legislature is considering Senate Bill 1527, which aims to eliminate out-of-pocket costs for cervical cancer screenings and procedures for residents. The bill was presented by Rep. Annessa Hartman, who shared her personal experience with cervical cancer to emphasize the importance of accessible screenings. The bill is modeled after a 2023 law that removed costs for breast examinations. It has received support from the American Cancer Society and the American College of Obstetricians and Gynecologists. The Senate Health Care committee has unanimously voted to advance the bill to the Senate floor with a recommendation for passage.