insitro's AI-Discovered MASH Candidate Shows Promise in Reducing Liver Fibrosis
Insitro, a company specializing in AI-driven drug discovery, presented new preclinical data at the American Diabetes Association's 86th Scientific Sessions. The data highlights the potential of their lead therapeutic candidate, CTRO-1013, in reducing fibrosis progression in metabolic dysfunction-associated steatohepatitis (MASH). The study demonstrated that liver-targeted silencing of IRS1, a genetic target identified by insitro's AI platform, lowered biomarkers associated with fibrosis and liver injury in preclinical models. These findings suggest that IRS1 inhibition could offer a new therapeutic approach for MASH, a chronic liver disease characterized by fat accumulation, inflammation, and fibrosis.