Midlife Telomere Length Linked to Perceived Stress and Chronic Disease, Not Fitness or Lifestyle
A recent cross-sectional study published in *Scientific Reports* investigated the relationship between telomere length, fitness, lifestyle habits, psychological stress, and chronic disease in middle-aged adults. Telomeres, the protective caps on chromosomes, shorten with age and are considered a marker of cellular aging. The study, conducted by researchers from Lithuanian universities, involved 84 adults with an average age of 51. Participants underwent various physical fitness assessments, provided blood samples for telomere length measurement, and completed questionnaires on lifestyle, sleep habits, and perceived stress. The findings indicated that after adjusting for age and sex, no measure of body composition, blood chemistry, muscle strength, aerobic fitness, physical activity, sleep, or sauna use was significantly linked to telomere length. Instead, higher perceived stress and older age were independently associated with shorter median telomere length and a lower 20th-percentile telomere length.