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Judith L. Rapoport's Legacy in Child Psychiatry and Neuropsychiatric Research

Judith L. Rapoport's Legacy in Child Psychiatry and Neuropsychiatric Research

Judith L. Rapoport, a pioneering figure in child psychiatry and neuropsychiatric research, passed away on March 7, 2026. Rapoport's work at the National Institute of Mental Health (NIMH) significantly advanced the understanding and treatment of disorders such as ADHD, OCD, and childhood-onset schizophrenia. Her research demonstrated the effectiveness of the antidepressant clomipramine in treating OCD in children and adolescents, leading to its FDA approval. Rapoport's team also used MRI technology to study brain development, revealing that many neuropsychiatric disorders are linked to abnormal growth trajectories. Her contributions have left a lasting impact on the field, influencing treatment approaches and research methodologies.
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In Memoriam: Judith L. Rapoport, Pioneering Child Psychiatrist

In Memoriam: Judith L. Rapoport, Pioneering Child Psychiatrist

Judith L. Rapoport, a renowned child psychiatrist, passed away on March 7, 2026. Rapoport was known for her contributions to the understanding and treatment of neuropsychiatric disorders such as ADHD, OCD, and childhood onset schizophrenia. Her work at the National Institute of Mental Health (NIMH) led to significant advancements in psychiatric research and treatment. Rapoport's legacy includes over 300 publications and mentorship of future leaders in the field.
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How Disgust Helps Humans Spot Potential Threats

How Disgust Helps Humans Spot Potential Threats

Disgust is a complex emotion with both biological and psychological components. It is not just a reaction to unpleasant stimuli; it involves intric...
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Cellenkos Receives FDA Clearance for New GVHD Treatment Trial

Cellenkos Receives FDA Clearance for New GVHD Treatment Trial

Cellenkos, a biotechnology company, has received FDA clearance to initiate a Phase 1b/2a clinical trial for CK0802, a new treatment for steroid-refractory graft-versus-host disease (GVHD). This condition occurs when donor T cells attack the recipient's organs following a stem cell transplant. Current treatments rely on high-dose steroids, which are often ineffective and leave patients vulnerable to infections. CK0802, a Treg therapy, aims to suppress inflammation and promote immune stability. The trial will evaluate the safety and efficacy of CK0802 in patients who have not responded to steroid therapy.
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Creatine's Potential Beyond Muscle Gains Explored by Scientists

Creatine's Potential Beyond Muscle Gains Explored by Scientists

Creatine's Potential Beyond Muscle Gains Explored by Scientists
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Study Suggests Estrogen in Brain Influences Trauma Response in Mice

Study Suggests Estrogen in Brain Influences Trauma Response in Mice

A recent study published in the journal Neuron suggests that estrogen levels in the brain's hippocampus may affect resilience to trauma. The research, conducted on mice, found that high estrogen levels in the hippocampus could worsen memory problems following traumatic events. The study observed that male mice and female mice in the proestrus phase, when estrogen peaks, showed more memory deficits after stress. In contrast, female mice in the estrus phase, with lower estrogen levels, demonstrated resilience. The findings indicate that local estrogen production in the brain plays a significant role in stress response.
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FDA Rejection Highlights Challenges in Gene Therapy Approvals

FDA Rejection Highlights Challenges in Gene Therapy Approvals

FDA Rejection Highlights Challenges in Gene Therapy Approvals
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Psilocybin Study Reveals Lasting Brain Changes and Mental Health Benefits

Psilocybin Study Reveals Lasting Brain Changes and Mental Health Benefits

A new study published in Nature Communications explores the effects of a single dose of psilocybin on brain activity and mental health. The research involved 28 participants who received a 1 mg placebo dose followed by a 25 mg dose of psilocybin. The study found that psilocybin can 'shake up' the brain's activity patterns, leading to increased psychological insight and improved mental well-being for up to a month. The researchers used various imaging techniques to measure brain activity and found a link between increased brain entropy and psychological benefits.
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Gene Therapy Faces Evidence Challenges Amid FDA Decisions

Gene Therapy Faces Evidence Challenges Amid FDA Decisions

Gene Therapy Faces Evidence Challenges Amid FDA Decisions
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Researchers Identify Sleep-Like Brain Waves as Key to Attention Lapses in ADHD

Researchers Identify Sleep-Like Brain Waves as Key to Attention Lapses in ADHD

Scientists have discovered that adults with attention deficit hyperactivity disorder (ADHD) experience brief patterns of brain activity, typically seen during deep sleep, intruding into their waking hours. This phenomenon is linked to frequent attention lapses and excessive daytime sleepiness in individuals with ADHD. The study, published in The Journal of Neuroscience, suggests that ADHD may be closely related to how the brain manages the boundary between sleep and wakefulness. Researchers conducted an experiment involving 63 young adults, including 32 diagnosed with ADHD, to observe their brain activity during a sustained attention task. The study found that individuals with ADHD exhibited a higher frequency of slow waves, which are indicative of localized brain regions entering a sleep-like state. These findings provide a potential explanation for the attentional difficulties experienced by those with ADHD.
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Researchers Face Challenges in Using AI for Mental Health Studies with Waitlist Controls

Researchers Face Challenges in Using AI for Mental Health Studies with Waitlist Controls

Researchers are increasingly using waitlist controls in empirical studies to assess the impact of AI on mental health. This method involves a treatment group using AI for mental health advice, while a control group waits to receive the same treatment later. The approach aims to compare the effects of AI intervention against doing nothing initially. However, this setup can lead to exaggerated treatment effects, as the control group may feel disadvantaged, potentially skewing results. The use of AI in mental health is growing, with millions using generative AI systems like ChatGPT for advice. Despite the potential benefits, concerns exist about AI providing inappropriate advice, highlighting the need for robust research to understand AI's impact on mental health.
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Study Links Sleep-Like Brain Waves to Attention Lapses in ADHD

Study Links Sleep-Like Brain Waves to Attention Lapses in ADHD

A study published in The Journal of Neuroscience has found that adults with attention deficit hyperactivity disorder (ADHD) experience sleep-like brain waves during waking hours, which may explain their attention lapses and daytime sleepiness. Researchers from Monash University and the Paris Brain Institute discovered that these slow waves, typically seen during deep sleep, occur more frequently in individuals with ADHD. The study involved 63 young adults, including 32 with ADHD, who underwent brain activity monitoring while performing attention tasks. The findings suggest a physical overlap between sleep and attention systems in the brain.