New Research Links Fructose to Cancer Spread, Emphasizes Limiting Added Sugars
Recent preclinical research, published in Nature Aging, suggests that fructose may influence the spread of certain cancer cells. The study found that fructose produced by chemotherapy-damaged ovarian cancer cells appeared to help nearby cancer cells break away and metastasize. Additionally, in mouse models, high amounts of dietary fructose promoted cancer spread even without prior chemotherapy exposure. Katherine M. Aird, PhD, a study coauthor, explained that fructose can make cancer cells less adhesive by causing them to lose cholesterol from their surface, facilitating their movement. Ana Gomes, PhD, another coauthor, noted that dietary fructose can also be converted by the liver into fats that tumors can utilize for growth. While these findings are preclinical and not yet confirmed in humans, they build upon previous studies linking fructose to cancer growth, including a 2024 study in Nature and a 2021 study in Cancer Research.