Exercise and Ibuprofen Show Promise in Reducing Cognitive Impairment During Chemotherapy
A Phase II clinical trial has revealed that exercise and low-dose ibuprofen may help mitigate cognitive impairments often experienced by cancer patients undergoing chemotherapy, commonly referred to as 'chemo brain.' The study, published in the journal CANCER, involved 86 participants who were randomly assigned to one of four groups: exercise plus placebo, exercise plus ibuprofen, ibuprofen only, and placebo only. The exercise regimen, known as EXCAP, consisted of home-based, low-to-moderate intensity walking and resistance exercises. Results indicated that participants in the exercise plus placebo group showed significant improvements in attention tests compared to the placebo group. Those who took ibuprofen also demonstrated better attention, although the benefits were less consistent. The study suggests that exercise may offer more pronounced cognitive benefits, while ibuprofen's effects require further investigation. 
