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New Enzyme Discovery Could Reverse Aging Effects in Human Tissue

New Enzyme Discovery Could Reverse Aging Effects in Human Tissue

Researchers at Revel Pharmaceuticals in San Francisco have developed an enzyme, known as CMLase, that may reverse aging effects in human tissue by clearing advanced glycation end products (AGEs). AGEs are compounds that accumulate in tissues and are associated with aging and inflammation. The enzyme was tested on human skin and arterial tissue, showing potential to reduce AGE levels significantly. This discovery, which involved the use of artificial intelligence to identify the enzyme, marks a promising step in anti-aging research, suggesting that it may be possible to reverse some aging-related changes at a structural level.
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Queensland Confirms First H5N1 Bird Flu Case, Urges Public Vigilance

Queensland Confirms First H5N1 Bird Flu Case, Urges Public Vigilance

Queensland has reported its first case of the H5N1 bird flu after a migratory petrel was found dead on Moreton Island. This marks Queensland as the fourth Australian state to confirm a case of this virulent strain, following Western Australia, South Australia, and New South Wales. The confirmation came after samples from the bird were tested by the Commonwealth Scientific and Industrial Research Organisation’s Australian Centre for Disease Preparedness. Since 2021, the H5N1 strain has been spreading through wild bird and mammal populations, causing significant fatalities and affecting poultry and dairy farms. Queensland authorities have emphasized the importance of public vigilance, advising residents to avoid contact with sick or dead birds and to report such findings to the Emergency Animal Disease Hotline.
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Georgia State University Develops Antiviral Drug GHP-88310 to Block Measles-Like Virus Transmission

Georgia State University Develops Antiviral Drug GHP-88310 to Block Measles-Like Virus Transmission

Georgia State University researchers have developed a new oral antiviral drug, GHP-88310, which has shown promising results in preventing the transmission of a measles-like virus in ferrets. The drug effectively blocked both direct contact and airborne transmission of the virus, which is similar to the canine distemper virus causing measles-like disease in ferrets. This development is significant as the United States has seen a resurgence in measles cases, with 2,260 cases reported by mid-July 2026, the highest since the disease was declared eliminated in 2000. The study, published in Nature Microbiology, highlights the drug's potential to augment traditional ring vaccination strategies, offering a new tool in controlling measles outbreaks.
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Ohio State Researchers Discover Noncoding RNA with Potential ATPase Function

Ohio State Researchers Discover Noncoding RNA with Potential ATPase Function

Researchers at The Ohio State University have identified a noncoding RNA derived from human cells that can bind to ATP, a molecule essential for cellular energy. This discovery challenges the traditional view that only proteins, specifically ATPases, can facilitate ATP's energy release. The team, led by Peixuan Guo, is exploring the RNA's function, hoping it mimics ATPase activity, which could lead to new therapeutic applications. This research builds on previous findings of viral RNA binding to ATP and aims to develop RNA-based nanomaterials for medical use.
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New Antiviral Drug GHP-88310 Shows Promise in Blocking Measles-Like Virus Transmission

New Antiviral Drug GHP-88310 Shows Promise in Blocking Measles-Like Virus Transmission

Researchers at Georgia State University have developed an oral antiviral drug, GHP-88310, which has shown effectiveness in preventing the transmission of a measles-like virus in ferrets. The study, published in Nature Microbiology, demonstrated that the drug blocked both direct contact and airborne transmission of the virus, significantly reducing clinical symptoms. The drug, a broad-spectrum orthoparamyxovirus polymerase inhibitor, was administered prophylactically and therapeutically, showing potential to augment traditional vaccination methods. The research aims to address the resurgence of measles cases in the U.S., attributed to declining vaccination rates.
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Georgia State University Researchers Develop Oral Drug to Block Measles-like Virus in Ferrets

Georgia State University Researchers Develop Oral Drug to Block Measles-like Virus in Ferrets

Researchers at Georgia State University's Center for Translational Antiviral Research have developed an oral antiviral drug candidate, GHP-88310, that effectively blocks the transmission of a measles-like virus in ferrets. The study, published in Nature Microbiology, demonstrates that the drug can prevent virus transmission through both direct contact and airborne exposure. The drug, a broad-spectrum inhibitor of the viral polymerase, was administered prophylactically and therapeutically, showing a reduction in clinical symptoms and transmission duration. This development is significant as measles has reemerged in the U.S. since 2025, with thousands of cases reported. The study's findings suggest that GHP-88310 could augment traditional vaccination methods, potentially aiding in outbreak management.
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Georgia State University Develops New Drug to Combat Measles Outbreaks

Georgia State University Develops New Drug to Combat Measles Outbreaks

Researchers at Georgia State University have developed an oral antiviral drug candidate, GHP-88310, that shows promise in blocking the transmission of a measles-like virus in ferrets. The study, published in Nature Microbiology, demonstrates that the drug can prevent both direct contact and airborne transmission of the virus. This development is significant as measles has reemerged in the United States, with thousands of cases reported since 2025. The drug could potentially augment traditional vaccination efforts, offering a new tool in controlling outbreaks.
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Research Identifies Neuronal Pathway for Itch Sensation in Mice, Potential for Human Treatment

Research Identifies Neuronal Pathway for Itch Sensation in Mice, Potential for Human Treatment

A recent study published in Neuron has identified a specific type of sensory neuron in mice that is responsible for transmitting the sensation of itch. The research, conducted by biologists at the University of Michigan, focused on vellus-like hairs in mice, which are connected to fast-conducting sensory neurons. These neurons transmit the sensation of itch with a light touch. The study suggests that these findings could be significant for developing treatments for human conditions such as eczema and insect bites. The researchers discovered that these neurons are modulated by a protein called Piezo2 and are transmitted by TLR5+ sensory neurons. This discovery could lead to new pathways for treating chronic itch in humans.
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Nona Biosciences and Medical University of Vienna Collaborate on Antibody Development

Nona Biosciences and Medical University of Vienna Collaborate on Antibody Development

Nona Biosciences and Medical University of Vienna Collaborate on Antibody Development
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Healthcare Experts Urge Shift to Infection Prevention Amid Rising Antibiotic Resistance

Healthcare Experts Urge Shift to Infection Prevention Amid Rising Antibiotic Resistance

Healthcare professionals and researchers are emphasizing the need for a fundamental shift in how bacterial infections are managed, focusing on infection prevention rather than solely on treatment. This call comes amid growing concerns over antimicrobial resistance (AMR), which has been identified as a significant global health threat. Despite repeated warnings, AMR has not been addressed with the urgency it requires. The World Health Organization (WHO) reports increasing resistance among many antibiotics, complicating clinical decision-making and placing additional pressure on healthcare systems. The current model of treating infections after they occur is becoming less viable as resistance grows, necessitating a reassessment of healthcare strategies. Infection prevention, including stronger control measures, improved surveillance, and vaccination, is being advocated as a central tenet of a new approach to managing bacterial infections.
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Georgia State University Researchers Develop Oral Drug to Block Measles-like Virus Transmission in Ferrets

Georgia State University Researchers Develop Oral Drug to Block Measles-like Virus Transmission in Ferrets

Researchers at Georgia State University's Center for Translational Antiviral Research have developed an oral antiviral drug candidate, GHP-88310, which effectively blocks the transmission of a measles-like virus in ferrets. The study, published in Nature Microbiology, demonstrates that the drug can prevent virus transmission both through direct contact and airborne exposure. The drug, a broad-spectrum inhibitor of the viral polymerase, was administered prophylactically, either shortly before or after exposure, and was found to reduce clinical symptoms and the period during which infected animals could transmit the virus. This development is significant as measles has reemerged in the United States since 2025, with thousands of cases and several deaths reported. The study's findings suggest that GHP-88310 could augment traditional ring vaccination strategies against measles.
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Bioengineering Advances: Hybrid Living Models Enhance Vascular Disease Research

Bioengineering Advances: Hybrid Living Models Enhance Vascular Disease Research

Recent developments in bioengineering have introduced hybrid living models that integrate both the bath and bioink as active components. These models are particularly promising for creating perfusable tubes with stiffness gradients and spatial heterogeneity of cell types, which are crucial for reconstructing vascularized tissue microenvironments. This approach allows for the exploration of interactions between arteries and their surrounding tissue environment, providing insights into various vascular diseases. The models are designed to mimic the structural and functional aspects of human vessels, enabling researchers to study the etiology of vascular diseases more effectively. The focus is on developing disease-aligned toolchains, including standardized bioinks and validated perfusion protocols, to deliver actionable physiological insights.