Shionogi's Ensitrelvir Shows Promise in Preventing COVID-19 Post-Exposure
A study published in the New England Journal of Medicine highlights the effectiveness of Shionogi's investigational oral antiviral, ensitrelvir, in preventing symptomatic COVID-19 following exposure. The Phase 3 SCORPIO-PEP study demonstrated that a five-day course of ensitrelvir reduced the risk of developing symptomatic COVID-19 by 67% compared to a placebo. The study involved 2,041 participants who were exposed to COVID-19 within their households. Ensitrelvir works by inhibiting viral replication, offering a potential new approach to preventing COVID-19. The drug is currently under review by the U.S. FDA for post-exposure prophylaxis, with a decision expected by June 16, 2026.