Study Identifies Factors Associated with Severe COVID-19 in Children Under 12
A recent case-control study conducted in Fuzhou, China, from January 2020 to August 2025, has identified several factors associated with severe COVID-19 outcomes in children under 12 years old. The study, which included 347 severe cases and 694 non-severe controls, found that male sex, age five years or younger, and home-based/preschool care were positively associated with severe disease. Additionally, children residing in rural areas, those with delayed medical consultation (more than two days after symptom onset), and those with pre-existing conditions such as obesity, chronic respiratory disease, or metabolic/endocrine disorders faced higher odds of severe COVID-19. Conversely, vaccination and caregiver disease-prevention awareness were inversely associated with severe outcomes. The study also noted that concurrent clinical indicators like fever lasting over three days, dyspnea/shortness of breath, and altered mental status were more frequent in severe cases, serving as warning signs for clinical deteri...