Fertility Gene PRDM9 Aids Glioblastoma Cells in Chemotherapy Resistance
Research from the University of Sydney has identified a fertility-linked gene, PRDM9, that helps glioblastoma cells resist chemotherapy. Glioblastomas, known for their high mortality rate, often recur after treatment. The study found that a subset of drug-tolerant cells, called persister cells, use PRDM9 to rewire their metabolism and survive chemotherapy. By blocking PRDM9 or cutting off cholesterol supply, researchers were able to eliminate these cells in models, suggesting a new therapeutic target. The study also developed a brain-penetrant chemotherapy drug, WJA88, paired with a cholesterol-lowering agent, showing promising results in preclinical models. 
