University of Notre Dame Researchers Investigate Neuron Death from Brain Compression
Researchers at the University of Notre Dame are exploring the mechanisms behind neuron death caused by chronic compression, such as that exerted by brain tumors. This study, published in the Proceedings of the National Academy of Sciences, aims to understand how to prevent neuron loss, which leads to sensory loss, motor impairment, and cognitive decline. The research team, led by Meenal Datta and Christopher Patzke, used induced pluripotent stem cells to create a model system of neurons and glial cells. They applied pressure to mimic the effects of a glioblastoma tumor, observing that chronic compression triggers neuron death through various mechanisms. The study found that compression activates self-destruction signaling in neurons and increases stress adaptive genes, leading to inflammation. These findings could help explain cognitive impairments and motor deficits in glioblastoma patients and offer potential drug targets to reduce neuronal death. 
