Dietary Polyphenols Show Promise in Modulating Inflammation and Cancer Pathways
A new review published in Food Science & Nutrition highlights the significant role of dietary polyphenols in modulating the nuclear factor kappa B (NF-κB) signaling pathway, which is crucial in chronic inflammation and various non-communicable diseases, including cancer. Researchers from Ajman University and King Khalid University conducted a comprehensive analysis, detailing how plant compounds found in foods like turmeric, green tea, grapes, berries, and soybeans can disrupt the molecular mechanisms that sustain chronic inflammation. The NF-κB pathway, while essential for immune response in healthy tissues, becomes a driver of malignancy when persistently activated, contributing to cancer development, cardiovascular disease, metabolic syndrome, and neurodegenerative conditions. The review outlines how specific polyphenols, such as curcumin from turmeric, resveratrol from grapes, and epigallocatechin gallate from green tea, intervene at various points in the NF-κB cascade to suppress its activity. These i... 
