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Patricia's Battle with Small Cell Lung Cancer Highlights Promise of T-Cell Engager Clinical Trial at Roswell Park

Patricia's Battle with Small Cell Lung Cancer Highlights Promise of T-Cell Engager Clinical Trial at Roswell Park

Patricia, a patient at Roswell Park Comprehensive Cancer Center, is experiencing an exceptional response to a Phase 1 clinical trial for small cell lung cancer (SCLC) using a new T-cell engager drug. Diagnosed with aggressive Stage 4 SCLC after already undergoing treatment for a brain tumor, Patricia initially felt unheard about her declining health. After transferring to Roswell Park and meeting with medical oncologist Dr. Prantesh Jain, she learned about the clinical trial. T-cell engagers are a type of immunotherapy that works by directing a patient's own immune system T cells to target and destroy cancer cells. This specific study drug targets a protein called delta-like ligand 3 (DLL3), found on most SCLC cells. A year into the trial, Patricia's lung tumors are shrinking, with one 40% smaller, and there is currently no evidence of disease progression. She attributes her improved health and renewed hope to the trial and the supportive care received at Roswell Park.
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Privo Technologies Announces 95.5% Complete Response Rate for Non-Surgical Oral Cancer Therapy PRV111 in Phase 2 Trial

Privo Technologies Announces 95.5% Complete Response Rate for Non-Surgical Oral Cancer Therapy PRV111 in Phase 2 Trial

Privo Technologies has announced positive results from its CLN-004 Phase 2 trial for PRV111, a nanoengineered, cisplatin-releasing patch designed to treat non-invasive oral cancer and high-grade dysplasia. The study, conducted at four major U.S. hospitals, involved 22 patients with biopsy-confirmed conditions. Twenty-one of these patients (95.5%) achieved a centrally confirmed pathologic complete response, meaning no residual dysplastic cells were found after treatment. The remaining patient was downstaged to low-grade dysplasia. Crucially, all 22 patients avoided the need for standard-of-care surgery, with treated lesions resolving and mucosal surfaces regenerating without scarring or distortion. At a median follow-up of 14 months, no recurrences were observed, and some patients have maintained responses for over 21 months. The treatment was well-tolerated, with negligible systemic cisplatin exposure and primarily mild, transient oral symptoms reported as treatment-related adverse events.
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Mayo Clinic Recognized as Top-Ranked Healthcare Provider, Emphasizes Employee Investment and National Presence

Mayo Clinic Recognized as Top-Ranked Healthcare Provider, Emphasizes Employee Investment and National Presence

Mayo Clinic, a not-for-profit organization, has been recognized by U.S. News & World Report as the top-ranked care provider in more specialties than any other institution. The organization operates three main campuses located in Phoenix/Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. Additionally, Mayo Clinic extends its reach through various Mayo Clinic Health System campuses across Midwestern communities and maintains international locations. The institution highlights its commitment to its employees by offering competitive compensation packages, comprehensive benefit plans, and continuous opportunities for education and career advancement. These benefits include multiple medical plan options, dental coverage through Delta Dental or reimbursement accounts, vision plans, pre-tax savings accounts like HSAs and FSAs, and competitive retirement packages. Mayo Clinic also ensures equal opportunity employment and provides reasonable accommodations for individuals with disabilities.
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Woman Diagnosed with Stage 4 Colon Cancer Days After Landing Dream Job

Woman Diagnosed with Stage 4 Colon Cancer Days After Landing Dream Job

Anastasia Sevriukova, a 25-year-old woman, received a diagnosis of stage 4 colon cancer just four days after securing her dream job as an aerospace engineer developing drones for Ukraine. Sevriukova initially dismissed symptoms like blood in her stool and fatigue, attributing them to stress. A CT scan later revealed the advanced stage of her cancer, which had spread to her liver, explaining symptoms like feeling drunk from one glass of wine due to liver dysfunction. She declined the job offer and moved to Rochester, Minnesota, for treatment, which included chemotherapy, antibody therapy, and a liver transplant. Despite being briefly cancer-free, new tumors were found on her lungs, requiring further treatment.
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Multidisciplinary Approach Emphasized for Stomach Cancer Treatment at Columbia Surgery

Multidisciplinary Approach Emphasized for Stomach Cancer Treatment at Columbia Surgery

At Columbia Surgery, a collaborative, multidisciplinary approach is crucial for treating stomach cancer, especially when tumors are located near the gastroesophageal junction, blurring the lines between gastric and esophageal diseases. Chief of Thoracic Surgery Joshua R. Sonett, MD, endocrine surgeon Beth A. Schrope, MD, PhD, FACS, and radiation oncologist David P. Horowitz, MD, highlight the importance of accurately identifying the cancer type as the first step in determining treatment. They explain that treatment decisions are made through team conferences involving various specialists, ensuring patients receive the most appropriate care tailored to their specific tumor characteristics, depth of invasion, size, nodal status, and presence of metastases. For early-stage cancers, endoscopic therapy may offer a cure, while more advanced stages often involve neoadjuvant chemotherapy followed by surgery. There is also a growing interest in organ preservation, with chemoradiation proving effective for certain s...
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Precision Medicine Platform Targets Acute Myeloid Leukemia with Personalized Therapies

Precision Medicine Platform Targets Acute Myeloid Leukemia with Personalized Therapies

A new research project, funded by IFAB and coordinated by Professor Giovanni Roti of the University of Parma, is developing a functional precision medicine platform to treat acute myeloid leukemia (AML). This initiative aims to move beyond conventional, often ineffective, treatments for AML, particularly in elderly patients. The project focuses on the individual variability of the disease, recognizing that cancer manifests differently in each patient. Researchers are utilizing advanced algorithms to test hundreds of non-commercialized pharmacological molecules on individual cancer cells. This approach significantly expands the scope of drug testing compared to the standard pool of about 15 drugs currently used for AML. The ultimate goal is to identify personalized therapeutic profiles that are more effective and can treat a larger percentage of patients who are currently considered untreatable. The project seeks to shift the paradigm from a one-size-fits-all treatment to therapies tailored to specific dise...
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Mayo Clinic Recognized as Top-Ranked Healthcare Provider, Offers Comprehensive Employee Benefits

Mayo Clinic Recognized as Top-Ranked Healthcare Provider, Offers Comprehensive Employee Benefits

Mayo Clinic has been recognized by U.S. News & World Report as the top-ranked care provider in more specialties than any other institution. This not-for-profit organization operates three main campuses in Phoenix/Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota, along with additional locations across Midwestern communities and internationally. The institution emphasizes a patient-first approach while also prioritizing its employees through competitive compensation and extensive benefit packages. These benefits include multiple medical plan options, Delta Dental or a reimbursement account for dental coverage, an affordable vision plan with a national network, pre-tax savings options like HSAs and FSAs, and a competitive retirement package. Mayo Clinic also promotes continuous education and career advancement opportunities, aiming to foster long-term employee success.
For the WinFor the Win
The NFL decided on whether it would punish two officials for unprofessional behavior

The NFL decided on whether it would punish two officials for unprofessional behavior

Two officials had heated outbursts directed at players on Sunday.
Vikings WireVikings Wire
The Good, Bad, and Ugly from Vikings' Week 4 win over the Dolphins

The Good, Bad, and Ugly from Vikings' Week 4 win over the Dolphins

The Minnesota Vikings are still undefeated after a Week 4 win against the Miami Dolphins, but it was anything but pretty once again.
AP NewsAP News
NFL suspends official Jeff Seeman 2 games, referee Adrian Hill 1 game for unprofessional conduct

NFL suspends official Jeff Seeman 2 games, referee Adrian Hill 1 game for unprofessional conduct

The NFL has suspended line judge Jeff Seeman two games for swearing at Arizona Cardinals tight end Trey McBride during the team’s loss to the New York Giants
SB NationSB Nation
Kickoff time announced for Michigan Football vs Penn State

Kickoff time announced for Michigan Football vs Penn State

The kickoff time has been announced for Michigan Football’s matchup against Penn State on October 17.
Palm Beach PostPalm Beach Post
When does daylight saving time end? Time change in Palm Beach County

When does daylight saving time end? Time change in Palm Beach County

The countdown to the end of daylight saving time 2026 is on, with the 'fall back' time change fast approaching.