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Inside St. Jude’s Fight Against Childhood Cancer—from Genome Mapping to Global Impact

Inside St. Jude’s Fight Against Childhood Cancer—from Genome Mapping to Global Impact

Jude Children's Research Hospital has been at the forefront of pediatric cancer research and treatment since its inception in 1962. Located in Memp...
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Deep Learning Model Developed to Predict Functional Impact of Regulatory Mutations

Deep Learning Model Developed to Predict Functional Impact of Regulatory Mutations

Deep Learning Model Developed to Predict Functional Impact of Regulatory Mutations
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Kelun-Biotech's Sacituzumab Tirumotecan Approved for New Breast Cancer Indication in China

Kelun-Biotech's Sacituzumab Tirumotecan Approved for New Breast Cancer Indication in China

Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. has announced the approval of a new indication for its TROP2-directed antibody-drug conjugate, sacituzumab tirumotecan (sac-TMT), by the National Medical Products Administration (NMPA) of China. This approval is for the treatment of adult patients with unresectable or metastatic HR+/HER2- breast cancer who have previously received endocrine therapy and at least one line of chemotherapy. The approval is based on positive results from the Phase III OptiTROP-Breast02 study, which demonstrated a significant increase in progression-free survival compared to chemotherapy. Sac-TMT is now approved for four indications in China, marking a significant milestone for Kelun-Biotech.
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Mavericks vs. Spurs Preview: 3 storylines as a rematch looms between in-state rivals

Mavericks vs. Spurs Preview: 3 storylines as a rematch looms between in-state rivals

The Mavericks gave the Spurs a scare in Dallas on Thursday in a 135-125 loss — now comes the home-and-home rematch.
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Friday Dots: Bitten by The Bug

Friday Dots: Bitten by The Bug

Injuries plague the Dawgs, and more for your Friday!
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George Coukos Appointed Director of Ludwig Laboratory for Cell Therapy, Advancing Cancer Immunotherapy

George Coukos Appointed Director of Ludwig Laboratory for Cell Therapy, Advancing Cancer Immunotherapy

The Ludwig Institute for Cancer Research has announced the establishment of the Ludwig Laboratory for Cell Therapy at Weill Cornell Medicine, led by Dr. George Coukos. Dr. Coukos, a renowned expert in tumor immunology and cellular immunotherapy, returns to the U.S. after a transformative tenure in Switzerland. His leadership is expected to advance the development of cellular-based cancer therapies, focusing on personalized treatments for various malignancies. The laboratory aims to enhance the specificity and potency of immune cells used in cancer treatment, addressing challenges like tumor heterogeneity and immunosuppressive environments.
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Study on Lung Cancer Cells' Metabolism Offers Insights for Improved Immunotherapy

Study on Lung Cancer Cells' Metabolism Offers Insights for Improved Immunotherapy

Researchers at the University of Queensland have conducted a study on the metabolism of lung cancer cells, revealing that glucose uptake plays a critical role in determining the effectiveness of immunotherapy. The study, published in Nature Communications, used machine learning to analyze cell interactions in non-small cell lung carcinoma (NSCLC). The findings suggest that higher glucose uptake in cancer cells is associated with poorer outcomes. This research aims to develop targeted treatments to enhance immunotherapy effectiveness, moving towards precision medicine where treatments are tailored to individual tumor profiles.
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Open Thread: Bleacher Report releases “The 50 Worst NBA Trades”

Open Thread: Bleacher Report releases “The 50 Worst NBA Trades”

With the trade deadline looming, it is important to remember to deal wisely
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Jaylen Brown scores 33 as Celtics beat Mavs 110-100 despite Flagg's 36 points

Jaylen Brown scores 33 as Celtics beat Mavs 110-100 despite Flagg's 36 points

Jaylen Brown had 33 points and 11 rebounds, and the Boston Celtics beat Dallas 110-100, overcoming another stellar showing from Cooper Flagg and handing the Mavericks their season-worst fifth consecutive loss
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Research Highlights Preventable Nature of Global Cancer Cases

Research Highlights Preventable Nature of Global Cancer Cases

A new study published in Nature Medicine reveals that nearly 40% of global cancer cases in 2022 were linked to modifiable risk factors, such as tobacco use, infections, and alcohol consumption. The research analyzed 36 cancer types across 185 countries, identifying significant opportunities for prevention through lifestyle changes and public health interventions. The study found that men were more affected by these risk factors than women, with smoking being the leading contributor to cancer cases in men, while infections were the primary risk factor for women. The findings emphasize the importance of targeted prevention strategies and improved data collection to reduce the global cancer burden.
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San Antonio vs Oklahoma City Thunder, Final Score: Spurs outlast the Thunder bench crew 116-106

San Antonio vs Oklahoma City Thunder, Final Score: Spurs outlast the Thunder bench crew 116-106

The Spurs struggle to put away a Thunder team missing most of the roster, but hold them off for a 10 point win
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Johnson, Wembanyama lead Spurs to 4th win over OKC, beating the injury-depleted Thunder 116-106

Johnson, Wembanyama lead Spurs to 4th win over OKC, beating the injury-depleted Thunder 116-106

Keldon Johnson scored 25 points, Victor Wembanyama had 22 points and 14 rebounds and the San Antonio Spurs never trailed in a 116-106 victory over injury-depleted Oklahoma City, beating the reigning NBA champion Thunder for a fourth time this season