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UCLA-Led Study Develops Clinical-Scale CRISPR Gene Correction for Sickle Cell Disease

UCLA-Led Study Develops Clinical-Scale CRISPR Gene Correction for Sickle Cell Disease

A new study has demonstrated the successful development of a clinical-scale manufacturing process capable of directly correcting the mutation responsible for sickle cell disease (SCD) in patients’ blood-forming stem cells. The experimental therapy, named CRISPR_SCD001, utilizes CRISPR-Cas9 technology along with a short, single-stranded DNA template to repair the sickle mutation within the beta-globin gene (HBB). The process involves collecting CD34-positive cells from mobilized peripheral blood, culturing them, and then using electroporation to introduce the CRISPR-Cas9 complex and corrective DNA template. These edited autologous cells are then intended for reinfusion into the patient after conditioning. This approach differs from currently approved gene therapies for SCD, which either add an anti-sickling gene via a lentiviral vector or edit a regulatory region to restore fetal hemoglobin production. CRISPR_SCD001 aims to directly repair the disease-causing mutation without a viral donor template. The man...
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UCLA Health Study Links Common Pesticide Chlorpyrifos to Increased Parkinson's Risk

UCLA Health Study Links Common Pesticide Chlorpyrifos to Increased Parkinson's Risk

A new study from UCLA Health indicates that long-term exposure to the widely used pesticide chlorpyrifos may significantly increase the risk of Parkinson's disease. The research suggests that individuals with prolonged residential exposure to chlorpyrifos face more than 2.5 times the risk of developing Parkinson's compared to those not similarly exposed. This finding is based on data from the Parkinson’s Environment and Genes study, which analyzed information from 829 people with Parkinson's and 824 without the condition, correlating their residential and workplace histories with detailed pesticide application records in California. Laboratory experiments involving mice exposed to aerosolized chlorpyrifos for 11 weeks showed movement difficulties, loss of dopamine-producing neurons, brain inflammation, and abnormal alpha-synuclein accumulations, mirroring key features of human Parkinson's. Further studies using zebrafish revealed that chlorpyrifos disrupts autophagy, a cellular cleanup process, leading to ...
SB NationSB Nation
Penn State Opens as Favorite Over Minnesota

Penn State Opens as Favorite Over Minnesota

The Nittany Lions did just enough to escape against Washington for their second consecutive victory on Saturday. The oddsmakers like the win streak to continue when Minnesota comes to Happy Valley on Saturday. Penn State has opened as a 7.5-point favorite, according to FanDuel. Penn State raced out to an impressive 28-6 halftime lead on […]
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National Institutes of Health Study Links Anti-Scl-70 Autoantibody Changes to Lung Function Decline in Systemic Sclerosis

National Institutes of Health Study Links Anti-Scl-70 Autoantibody Changes to Lung Function Decline in Systemic Sclerosis

A study led by Dr. Eric W. Robbins, Clinical Fellow at the Critical Care Medicine and Pulmonary Branch of the National Heart, Lung, and Blood Institute, National Institutes of Health, has found a significant association between serial quantitative changes in anti-Scl-70 autoantibody levels and subsequent lung function decline in systemic sclerosis (SSc). The research, presented at ACR Convergence 2026, utilized a luciferase immunoprecipitation systems (LIPS) assay to evaluate patients from the multicenter CONQUER registry. The findings indicate that early increases in anti-Scl-70 levels consistently correlated with worsening pulmonary function. This suggests that tracking the trajectory of autoantibody levels over time can provide prognostic information beyond a single baseline measurement, offering a more dynamic understanding of disease progression in SSc patients. The study aims to identify patients at greater risk for future pulmonary worsening by using serial antibody measurements as a dynamic biomark...
Gators WireGators Wire
Florida left voteless in US LBM Coaches Poll after Oklahoma loss

Florida left voteless in US LBM Coaches Poll after Oklahoma loss

After its fourth loss in the last five games, Florida football are now voteless in the US LBM Coaches Polls after Week 10.
Wolverines WireWolverines Wire
US LBM Coaches Poll: All three remaining Michigan opponents ranked

US LBM Coaches Poll: All three remaining Michigan opponents ranked

Michigan football faces a difficult road ahead with three ranked opponents left after losing to Michigan State.
USA TodayUSA Today
College football rankings after Week 10: Updated US LBM Coaches Poll, AP Top 25

College football rankings after Week 10: Updated US LBM Coaches Poll, AP Top 25

How will the Week 9 college football results affect the updated Week 11 Coaches poll and AP Top 25 rankings? Here's what to know.
USA TodayUSA Today
College Football Playoff Predictor: Georgia looks downright unbeatable

College Football Playoff Predictor: Georgia looks downright unbeatable

Georgia has emerged as the team nobody wants to face, taking the No. 1 spot in our College Football Playoff Predictor after a dominant win.
Gators WireGators Wire
Florida falls, remains in FPI top 30 after Week 10 loss to Oklahoma

Florida falls, remains in FPI top 30 after Week 10 loss to Oklahoma

The Florida Gators' Week 10 loss to Oklahoma once again sent them tumbling down the Football Power Index rankings, but they remain among the top 30.
UCLA WireUCLA Wire
What did Bob Chesney think of UCLA's Week 10 win over Minnesota?

What did Bob Chesney think of UCLA's Week 10 win over Minnesota?

UCLA first-year head coach Bob Chesney spoke postgame about the Bruins' 34-20 win over Minnesota on Saturday.
UCLA WireUCLA Wire
Bob Chesney speaks on UCLA's deep scores to Aidan Mizell in Week 10

Bob Chesney speaks on UCLA's deep scores to Aidan Mizell in Week 10

Bob Chesney spoke about the offense of the UCLA Bruins, with the team finding Aidan Mizell for two big touchdowns.
Hawkeyes WireHawkeyes Wire
Iowa football climbs rankings in new US LBM Coaches Poll

Iowa football climbs rankings in new US LBM Coaches Poll

Iowa made another jump in the latest US LBM Coaches Poll after their 24-10 win at Northwestern on Saturday night.