Grand Challenges Initiative Funds Innovations for Low-Cost Pathogen Sequencing in Public Health
Grand Challenges, in collaboration with the Gates Foundation, Temasek Foundation, and the United Nations Foundation, has launched a call for proposals to fund innovations in low-cost and simplified pathogen sequencing workflows. The initiative aims to address significant barriers preventing routine pathogen genomic sequencing in public health laboratories, particularly in low- and middle-income countries (LMICs). These barriers include high sequencing costs, complex laboratory workflows, limited technical capacity, infrastructure constraints, and long turnaround times. The program offers awards of up to US$800,000 for projects that develop scalable, simplified, and affordable sequencing approaches for pathogen surveillance and outbreak response, with a target per-sample cost of approximately US$1–10. The initiative seeks both technological and operational innovations to make pathogen sequencing cheaper, simpler, faster, and easier to deploy routinely.