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Brooke Eby, Beloved TikTok Star and ALS Activist, Dead at 37

Brooke Eby, Beloved TikTok Star and ALS Activist, Dead at 37

Friends, family, and followers remember her as a defining voice in ALS awareness.
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Mount Sinai Researchers Uncover Reversible Mechanisms of Alzheimer's Disease Linked to APOE4 Gene

Mount Sinai Researchers Uncover Reversible Mechanisms of Alzheimer's Disease Linked to APOE4 Gene

Researchers at the Icahn School of Medicine at Mount Sinai have identified new details regarding how the APOE4 gene, a significant genetic risk factor for Alzheimer's disease, contributes to brain damage. Two studies published in 'Cell' and 'Cell Stem Cell' reveal that APOE4 can damage blood vessels in the brain and promote the accumulation of abnormal proteins associated with neurodegenerative diseases. The findings suggest that these disease processes may be reversible. Specifically, the Cell study found that APOE4 alters pericytes, cells that stabilize small blood vessels, causing them to transform into myofibroblast-like cells that produce scar tissue. This transformation leads to vascular fibrosis and increased amyloid buildup around blood vessels, potentially interfering with blood flow and fostering neurodegeneration. The researchers demonstrated that blocking TGF-β signaling could reverse this process in aged APOE4 mice. The Cell Stem Cell study utilized miBrains, a 3D human brain tissue model deve...
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Flash Fiction Gains Recognition as Underrated Literary Form Amidst Digital Consumption Trends

Flash Fiction Gains Recognition as Underrated Literary Form Amidst Digital Consumption Trends

Flash Fiction Gains Recognition as Underrated Literary Form Amidst Digital Consumption Trends
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National MS Society Launches $1 Billion Campaign to End MS, Raises $12 Million at Gala

National MS Society Launches $1 Billion Campaign to End MS, Raises $12 Million at Gala

The National Multiple Sclerosis Society has initiated a five-year, $1 billion Campaign to End MS, marking its most ambitious effort in its 80-year history. The campaign officially launched with a day of events in New York City, culminating in a gala at Cipriani 42nd Street. This event successfully raised over $12 million towards advancing MS research. The campaign aims to accelerate research breakthroughs, enhance access to care and support for individuals living with MS, and ultimately work towards a future free of the disease. Nearly 500 guests attended the gala, which featured prominent advocates and supporters, including Jack Osbourne, and honored singer David Osmond and his family for their commitment to the MS community. The day also included a national research symposium, 'Big Bets for Breakthroughs,' where leading researchers discussed strategies to stop MS progression, restore function, and prevent the disease.
USA TodayUSA Today
The Saints came home after Katrina. What happened next changed New Orleans

The Saints came home after Katrina. What happened next changed New Orleans

The New Orleans Saints return to the Superdome a year after Hurricane Katrina featured a moment so big they made it a statue where fans still gather 20 years later.
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Mount Sinai Researchers Identify Reversible Weakness in Alzheimer's Risk Gene APOE4, Offering New Therapeutic Targets

Mount Sinai Researchers Identify Reversible Weakness in Alzheimer's Risk Gene APOE4, Offering New Therapeutic Targets

Mount Sinai researchers have made significant discoveries regarding the APOE4 gene, the most potent genetic risk factor for Alzheimer's disease. Two studies published in 'Cell' and 'Cell Stem Cell' reveal that APOE4 damages brain blood vessels and promotes the accumulation of abnormal proteins linked to neurodegenerative diseases. Specifically, APOE4 alters pericytes, cells that normally stabilize small blood vessels, transforming them into myofibroblast-like cells that produce scar tissue. This leads to vascular fibrosis and increased amyloid buildup around blood vessels, potentially hindering blood flow and fostering neurodegeneration. The research also found that APOE4 causes cholesterol accumulation in astrocytes, impairing their waste-disposal system and leading to the buildup of alpha-synuclein, a protein associated with Lewy body dementia and Parkinson's disease. Crucially, the studies indicate that these processes may be reversible, with blocking TGF-β signaling restoring pericyte coverage and redu...
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Edikted Seeks Senior Trend Forecaster to Identify Commercial Styles

Edikted Seeks Senior Trend Forecaster to Identify Commercial Styles

Edikted Seeks Senior Trend Forecaster to Identify Commercial Styles
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Mayo Clinic Researchers Report Early Success in Genetic ALS Therapy for Single Patient

Mayo Clinic Researchers Report Early Success in Genetic ALS Therapy for Single Patient

Mayo Clinic researchers have reported encouraging early results from an experimental therapy designed for a single patient with a rare genetic form of amyotrophic lateral sclerosis (ALS). The study, published in Med, highlights the potential of precision medicine to target the genetic causes of diseases, especially for rare conditions with limited treatment options. The patient's ALS was linked to a mutation in the CHCHD10 gene, which makes the protein harmful to nerve cells and is associated with abnormal changes in TDP-43, a protein connected to ALS. Researchers collaborated with the n-Lorem Foundation to develop an experimental antisense oligonucleotide (ASO) therapy. This ASO is designed to bind to RNA and reduce the production of the harmful protein. The patient received six doses of the experimental ASO through spinal cord injections, which were well-tolerated. Early indicators show a significant reduction in neurofilament light, a biomarker for nerve-cell injury, and stable or modestly improved meas...
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Alzheimer's Biology Exacerbates Long-Term Brain Damage After Traumatic Brain Injury, Study Finds

Alzheimer's Biology Exacerbates Long-Term Brain Damage After Traumatic Brain Injury, Study Finds

New research from the University of Miami Miller School of Medicine indicates that Alzheimer's disease-related biology intensifies chronic inflammation and brain damage following traumatic brain injury (TBI). The study, led by investigators at The Miami Project to Cure Paralysis, found that individuals with Alzheimer's-associated biological changes experienced more severe chronic inflammation, greater brain tissue loss, and higher levels of neurodegeneration markers after TBI. Specifically, if a traumatic brain injury occurs in someone with Alzheimer's disease, the inflammatory response persists chronically instead of subsiding, unlike in individuals without Alzheimer's. This persistent inflammation is linked to increased loss of brain tissue in regions vital for memory and cognition, such as the cortex and hippocampus. The research also identified elevated levels of glial fibrillary acidic protein (GFAP) and neurofilament light (NfL), markers associated with chronic neuroinflammation and axonal damage, re...
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Senate Passes Bipartisan ACT for ALS Reauthorization Act, Awaiting President's Signature

Senate Passes Bipartisan ACT for ALS Reauthorization Act, Awaiting President's Signature

The U.S. Senate has passed the Access to Critical Therapies for ALS Reauthorization Act (ACT for ALS Reauthorization Act) of 2026 with bipartisan support. This legislation, spearheaded in the House by Representatives Mike Quigley (IL-05) and Ken Calvert (CA-41), and in the Senate by Senators Lisa Murkowski (R-AK) and Chris Coons (D-DE), aims to renew and expand programs established by the original 2021 ACT for ALS. The reauthorization will continue to advance scientific understanding of neurodegenerative diseases and facilitate access to promising new treatments for individuals living with Amyotrophic Lateral Sclerosis (ALS). The bill also codifies the Department of Health and Human Services’ (HHS) interpretation of Expanded Access Program eligibility guidelines and mandates the Food and Drug Administration (FDA) to develop a new 5-year Action Plan specifically for rare neurodegenerative diseases. The legislation has garnered endorsements from several key organizations, including I AM ALS, the Muscular Dys...
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Dr. Richard Bedlack's Bold Fashion Statement Redefines ALS Patient Care

Dr. Richard Bedlack's Bold Fashion Statement Redefines ALS Patient Care

Dr. Richard Bedlack, a neurologist, is challenging traditional approaches to ALS care through his unique philosophy that integrates bold fashion and optimism. This innovative method is highlighted in the documentary film 'Stitching Strength,' which focuses on the fight against ALS, a terminal disease that progressively diminishes bodily control. Dr. Bedlack's approach emphasizes that fashion is more than just clothing; it's an expression of joy, a conversation starter, and a defense against despair, effectively becoming a form of medicine. The documentary showcases how patients, despite their diagnosis, are reclaiming their identities and expressing themselves through style. This initiative aims to transform grief into art, music, and action, demonstrating that strength and possibility can still be found even in the face of a debilitating illness. The film and Dr. Bedlack's work underscore the power of believing in what remains possible for those living with ALS.
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Philadelphia Eatery Jordan Johnson's Achieves Viral Success with Buttermilk Fried Fish Hoagies

Philadelphia Eatery Jordan Johnson's Achieves Viral Success with Buttermilk Fried Fish Hoagies

Philadelphia Eatery Jordan Johnson's Achieves Viral Success with Buttermilk Fried Fish Hoagies