DNA Methylation Emerges as Potential Factor in Delirium Pathophysiology, Review Suggests
A systematic review published in Epigenetics Communications has explored the potential role of DNA methylation in the pathophysiology of delirium, a common and serious complication in hospitalized older adults. Delirium, characterized by acute disturbances in attention and awareness, is associated with longer hospital stays, accelerated cognitive decline, and increased mortality. The review, led by Jim Jacob and Federica Sarno, aimed to determine if methylation changes could bridge the gap between predisposing vulnerabilities (like age and neurodegeneration) and acute precipitating factors (such as inflammation or surgery). Out of 1,110 potentially relevant articles, only nine met the inclusion criteria, indicating a limited but growing body of empirical evidence. The studies examined differential DNA methylation at specific CpG sites or age-related methylation patterns. While robust evidence is still lacking, some intriguing signals emerged, particularly concerning inflammation and neurotrophic signaling.... 
