Study Reveals Vagal Mechanoreceptors' Role in Blood Volume Regulation
A recent study published in Nature highlights the role of vagal mechanoreceptors in the heart, specifically PIEZO2 neurons, in responding to changes in blood volume to stabilize blood pressure during postural changes. The research, led by Liberles and colleagues, demonstrates that these neurons are crucial in compensating for gravitational changes, which could lead to neurogenic postural hypotension if dysfunctional. The study involved genetic manipulation in mice, revealing that PIEZO2 neurons are essential for maintaining blood pressure and heart rate during blood volume changes, such as those experienced during traumatic hemorrhage. 
