Low-Dose THC Shows Promise in Stabilizing Breast Cancer Cells, Preventing Aggressive Reversion in Tumor Models
Researchers have discovered that low doses of THC (tetrahydrocannabinol), a compound found in cannabis, can prevent aggressive breast cancer cells from reverting to a more stem-like, treatment-resistant state. The study, published in Communications Biology, involved treating 3D tumor models (organoids) derived from mouse breast tumors and patient samples with low-dose THC for four days. After the treatment, the organoids did not return to an aggressive state. Instead, they remained in a mature, luminal-like state, similar to the cells lining the breast's milk ducts, and exhibited a reduced capacity to self-renew or form new tumors. This effect was sustained even when the treated organoids were exposed to environmental stressors that typically induce aggressive behavior in cancer cells. The research indicates that modulating the CB2R receptor within the endocannabinoid system plays a crucial role in this stabilization, suggesting a potential new strategy for managing breast cancer by resetting cell identity... 
