Northwestern University Scientists Identify Neurons Linked to Cannabinoid-Induced Anxiety in Mice
Scientists at Northwestern University have identified a specific group of neurons in the central nucleus of the amygdala that may be responsible for anxiety-like behavior induced by cannabinoids under stressful conditions. The study, published on October 2 in the journal Nature Communications, involved experiments with mice exposed to a threatening odor derived from fox urine. Before exposure, mice were administered either a placebo or a synthetic cannabinoid drug. The researchers observed that mice given the cannabinoid exhibited increased freezing behavior and reduced exploration of the odor source, indicating heightened anxiety. This behavior correlated with increased activity of somatostatin neurons in the central nucleus of the amygdala, a brain region known for its role in processing fear and stress. Brain activity was monitored using a small implanted microscope, and analysis of brain tissue revealed that the cannabinoid weakened a natural mechanism that typically restrains the activity of these som...
