Purdue University Researchers Develop Conductive Polymers for Brain Interfaces with Minimal Side Effects
Researchers at Purdue University, led by Jianguo Mei, PhD, have developed a method to create conductive polymers directly within biological tissues, specifically in the brain. This innovative approach involves the in vivo assembly of n-doped poly(benzodifurandione) (n-PBDF) from monomers injected into organisms. The process utilizes the organism's native catalysts, such as hemoproteins found in blood, to facilitate polymer formation. The research, published in Science, demonstrated the safety and efficacy of this method in zebrafish and mice, showing no adverse effects on behavior or physiology. The polymers formed stable deposits without causing inflammation or neural cell loss, and they effectively altered neuronal activity by impacting sodium and potassium channels. The effects could be reversed using two-photon near-infrared light stimulation, allowing for precise control of neuronal behavior.