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NFL Week 5 game picks: Odds and expert predictions for every matchup

NFL Week 5 game picks: Odds and expert predictions for every matchup

The NFL schedule is jam-packed again with huge matchups in Week 5. Here's a breakdown of expert picks, predictions and the latest odds for every game.

Make your Week 5 NFL Picks

Make your Week 5 NFL Picks

Are we getting a Super Bowl preview in Week 5 prime time?

Matthew Stafford's Performance Under Scrutiny Despite Los Angeles Rams' Victory

Matthew Stafford's Performance Under Scrutiny Despite Los Angeles Rams' Victory

Matthew Stafford's Performance Under Scrutiny Despite Los Angeles Rams' Victory

Rams Injury Report: Mumpfield, Forbes suffer minor injuries

Rams Injury Report: Mumpfield, Forbes suffer minor injuries

Rams are still nursing major and minor ailments heading into Week 5

Puka Nacua shows he's still the catalyst of the Rams' offense in comeback win after injury absence

Puka Nacua shows he's still the catalyst of the Rams' offense in comeback win after injury absence

Most of the headlines involving Los Angeles Rams wide receiver Puka Nacua this year have been about off-field issues

Rochester Democrat and Chronicle

Pressure shifts to Bills ahead of Rams showdown

Pressure shifts to Bills ahead of Rams showdown

Coming off their first loss of the season, the Bills now face a supremely tough test against the Rams. Here's an early look ahead to the matchup.

AP NFL Power Rankings Week 5: Top 5 gets shaken up

AP NFL Power Rankings Week 5: Top 5 gets shaken up

The Arrowhead Pride team ranks the league from top to bottom.

The Rams need to beat the Bills

The Rams need to beat the Bills

The Rams can’t take the road to the wild card if they want to be the Super Bowl champions they were predicted to be

NFL Week 5 Power Rankings: Biggest Area Of Concern For Each Team

NFL Week 5 Power Rankings: Biggest Area Of Concern For Each Team

Week 4 of the 2026 NFL season is in the books, so @AaronLemingNFL examines each team’s biggest area of concern heading into Week 5.

Rams ‘hope’ Aaron Donald is back for Week 5

Rams ‘hope’ Aaron Donald is back for Week 5

Aaron Donald could be back in Week 5 and more NFL related news on a Tuesday

Rams protecing Aaron Donald 'from himself' by holding him out

Rams protecing Aaron Donald 'from himself' by holding him out

Sean McVay admits Aaron Donald could probably play if he wanted to, but the Rams want to protect him from making his back worse.

Rochester Democrat and Chronicle

Early Bills vs. Rams predictions offer Buffalo a glimmer of hope

Early Bills vs. Rams predictions offer Buffalo a glimmer of hope

One analyst thinks a certain Bills player could save the day for Buffalo.