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49ers vs Cardinals asks a simple question: How big is the gap?

49ers vs Cardinals asks a simple question: How big is the gap?

The San Francisco 49ers host the Arizona Cardinals at Levi's Stadium on Sept. 27 and USA TODAY's NFL experts have locked in their picks against the spread for the action.
AP NewsAP News
Purdy throws 4 TD passes to lead the injury-depleted 49ers to a 36-30 win vs. the Cardinals

Purdy throws 4 TD passes to lead the injury-depleted 49ers to a 36-30 win vs. the Cardinals

Brock Purdy threw four touchdown passes with the first coming on a trick play and the injury-depleted San Francisco 49ers held on for a 36-30 victory over the Arizona Cardinals
Sportsbook WireSportsbook Wire
Arizona Cardinals at San Francisco 49ers odds, picks and predictions

Arizona Cardinals at San Francisco 49ers odds, picks and predictions

The Arizona Cardinals and San Francisco 49ers clash in Week 2 in Santa Clara, California, at 4:05 p.m. ET.
SB NationSB Nation
49ers vs. Cardinals: How to watch, game time, and betting odds

49ers vs. Cardinals: How to watch, game time, and betting odds

It’s Week 3 and the Cardinals are coming to town. Here’s everything you need to know
SB NationSB Nation
Arizona Cardinals-San Francisco 49ers 2026 week three discussion thread

Arizona Cardinals-San Francisco 49ers 2026 week three discussion thread

Talk about the Arizona Cardinals game against the San Francisco 49ers.
SB NationSB Nation
Brock Purdy bails out the 49ers’ defense in a shootout win over the Cardinals

Brock Purdy bails out the 49ers’ defense in a shootout win over the Cardinals

The 49ers were decimated by injuries, but held on with a home win.
AP NewsAP News
The 49ers dial up a hook-and-ladder play to open scoring against the Cardinals

The 49ers dial up a hook-and-ladder play to open scoring against the Cardinals

The San Francisco 49ers went deep in the playbook to open up the scoring against the Arizona Cardinals
SB NationSB Nation
49ers numbers to know: The Cardinals have a long NFC West streak on the line

49ers numbers to know: The Cardinals have a long NFC West streak on the line

Plus, the lack of 49ers pass rush
AP NewsAP News
Receiver Mike Evans is ruled out for the 49ers with a rib injury

Receiver Mike Evans is ruled out for the 49ers with a rib injury

San Francisco 49ers receiver Mike Evans left the game against the Arizona Cardinals in the first half with a rib injury and won’t return
AP NewsAP News
49ers coach Kyle Shanahan faces another disciple in game against Cardinals coach Mike LaFleur

49ers coach Kyle Shanahan faces another disciple in game against Cardinals coach Mike LaFleur

San Francisco 49ers coach Kyle Shanahan said he might appreciate one day how many assistants that used to work under him have become head coaches in the NFL
Arizona RepublicArizona Republic
Can the Arizona Cardinals upset the 49ers? Breaking down the matchup

Can the Arizona Cardinals upset the 49ers? Breaking down the matchup

The Arizona Cardinals are looking to get right against the San Francisco 49ers in Week 3, after a demoralizing blowout loss to the Seattle Seahawks.
Niners WireNiners Wire
George Kittle credits one key factor in 49ers' hot 2-0 start

George Kittle credits one key factor in 49ers' hot 2-0 start

The 49ers retained a lot of key offensive personnel that helped them cruise to a 2-0 record to start 2026.