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The 49ers are running into the stingiest defense in the NFL

The 49ers are running into the stingiest defense in the NFL

Three numbers to watch heading into Week 5 between the 49ers and Seahawks
AP NewsAP News
The 49ers travel to face the Seahawks in their 1st meeting since last season's playoff loss

The 49ers travel to face the Seahawks in their 1st meeting since last season's playoff loss

Games between the San Francisco 49ers and Seattle Seahawks are typically intense with the two rivals often competing for NFC West supremacy
SB NationSB Nation
49ers News: One more sleep until the game of the year (so far)

49ers News: One more sleep until the game of the year (so far)

Your daily San Francisco 49ers news for Saturday, October 10th, 2026
SB NationSB Nation
NFL predictions: Jaxon Smith-Njigba will dominate for Seahawks vs. 49ers

NFL predictions: Jaxon Smith-Njigba will dominate for Seahawks vs. 49ers

Seattle’s star could go supernova against the 49ers. Again.
Broncos WireBroncos Wire
All 32 NFL quarterbacks (including Bo Nix) ranked by Total QBR in Week 5

All 32 NFL quarterbacks (including Bo Nix) ranked by Total QBR in Week 5

Broncos QB Bo Nix ranks 25th among current NFL starters with a 46.1 Total QBR rating going into Week 5.
SB NationSB Nation
Previewing the Week 5 Seahawks-49ers matchup with KMA Sports

Previewing the Week 5 Seahawks-49ers matchup with KMA Sports

Field Gulls own JPG joined KMA sports to preview the Week 5 Seahawks-49ers matchup.
Seahawks WireSeahawks Wire
Seahawks have special home winning streak on line in Week 5 vs. 49ers

Seahawks have special home winning streak on line in Week 5 vs. 49ers

The Seahawks will look to secure their 10th straight win at home against the 49ers on Sunday.
Arizona RepublicArizona Republic
NFL Week 5 predictions, picks, win probabilities for games this week

NFL Week 5 predictions, picks, win probabilities for games this week

NFL Week 5 picks, predictions, win probabilities for Buccaneers vs Cowboys, Eagles vs Jaguars, Bengals vs Dolphins, Raiders vs Patriots, more games.
SB NationSB Nation
49ers-Seahawks: 3 major differences from last year’s roster

49ers-Seahawks: 3 major differences from last year’s roster

The 49ers overhauled their roster at wide receiver, plus they have some key pieces returning who didn’t play late against the Seahawks last season
SB NationSB Nation
49ers News: TIL the practice squad has an injured reserve

49ers News: TIL the practice squad has an injured reserve

Your daily San Francisco 49ers news for Thursday, October 8th, 2026
Niners WireNiners Wire
49ers take No. 1 in nearly every Week 5 power ranking

49ers take No. 1 in nearly every Week 5 power ranking

The 49ers are one of the only remaining undefeated teams, so it makes sense they'd be at or near the top of the NFL's Week 5 power rankings.
For the WinFor the Win
NFL picks against the spread for Week 5 from our expert staff

NFL picks against the spread for Week 5 from our expert staff

Our panel of experts is back to give you picks against the spread for every game on a loaded Week 5 slate.