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San Francisco 49ers at Seattle Seahawks odds, picks and predictions

San Francisco 49ers at Seattle Seahawks odds, picks and predictions

The San Francisco 49ers and their division rival Seattle Seahawks meet Sunday at Lumen Field in Seattle, Washington. Kickoff is set for 4:25 p.m. ET.

Seahawks have special home winning streak on line in Week 5 vs. 49ers

Seahawks have special home winning streak on line in Week 5 vs. 49ers

The Seahawks will look to secure their 10th straight win at home against the 49ers on Sunday.

49ers News: One more sleep until the game of the year (so far)

49ers News: One more sleep until the game of the year (so far)

Your daily San Francisco 49ers news for Saturday, October 10th, 2026

NFL predictions: 49ers and Seahawks feel like a low-scoring game

NFL predictions: 49ers and Seahawks feel like a low-scoring game

It’s a day for the 49ers linebackers

5 matchups to watch in 49ers-Seahawks: The 1 player Brock Purdy should avoid

5 matchups to watch in 49ers-Seahawks: The 1 player Brock Purdy should avoid

Highlighting 5 players to watch on the Seahawks. The 49ers should attack a couple of them.

The 49ers travel to face the Seahawks in their 1st meeting since last season's playoff loss

The 49ers travel to face the Seahawks in their 1st meeting since last season's playoff loss

Games between the San Francisco 49ers and Seattle Seahawks are typically intense with the two rivals often competing for NFC West supremacy

NFL predictions: Jaxon Smith-Njigba will dominate for Seahawks vs. 49ers

NFL predictions: Jaxon Smith-Njigba will dominate for Seahawks vs. 49ers

Seattle’s star could go supernova against the 49ers. Again.

The 49ers are running into the stingiest defense in the NFL

The 49ers are running into the stingiest defense in the NFL

Three numbers to watch heading into Week 5 between the 49ers and Seahawks

Behind Enemy Lines: 5 things to know about the San Francisco 49ers

Behind Enemy Lines: 5 things to know about the San Francisco 49ers

Join us as we take you on a journey behind enemy lines!

Previewing the Week 5 Seahawks-49ers matchup with KMA Sports

Previewing the Week 5 Seahawks-49ers matchup with KMA Sports

Field Gulls own JPG joined KMA sports to preview the Week 5 Seahawks-49ers matchup.

3 things to watch for in Seahawks’ Week 5 matchup vs. 49ers

3 things to watch for in Seahawks’ Week 5 matchup vs. 49ers

Injuries, MVP-caliber players and defensive objectives will be on center stage in Week 5 and dictate how the Seahawks’ matchup against the 49ers goes.

Seahawks News: Do the Seahawks have an RB problem?

Seahawks News: Do the Seahawks have an RB problem?

May take the whole season to figure out who the number one back is.