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3 bold predictions for Seahawks’ Week 5 matchup vs. 49ers

3 bold predictions for Seahawks’ Week 5 matchup vs. 49ers

Jaxon Smith-Njigba headlines the many variables that may dictate the course of the game on Sunday.

Sportsbook Wire

San Francisco 49ers at Seattle Seahawks odds, picks and predictions

San Francisco 49ers at Seattle Seahawks odds, picks and predictions

The San Francisco 49ers and their division rival Seattle Seahawks meet Sunday at Lumen Field in Seattle, Washington. Kickoff is set for 4:25 p.m. ET.

WATCH: Seahawks blow up 49ers punt return, recover fumble

WATCH: Seahawks blow up 49ers punt return, recover fumble

This is the second muffed punt the Seahawks have recovered in the past two weeks

49ers News: One more sleep until the game of the year (so far)

49ers News: One more sleep until the game of the year (so far)

Your daily San Francisco 49ers news for Saturday, October 10th, 2026

3 keys to a 49ers win over the Seahawks: Is this the Brock Purdy revenge game?

3 keys to a 49ers win over the Seahawks: Is this the Brock Purdy revenge game?

The 49ers are underdogs on the road on Sunday.

NFL predictions: 49ers and Seahawks feel like a low-scoring game

NFL predictions: 49ers and Seahawks feel like a low-scoring game

It’s a day for the 49ers linebackers

Seahawks have special home winning streak on line in Week 5 vs. 49ers

Seahawks have special home winning streak on line in Week 5 vs. 49ers

The Seahawks will look to secure their 10th straight win at home against the 49ers on Sunday.

WATCH: Seahawks DT Byron Murphy II takes 49ers over with 2 sacks

WATCH: Seahawks DT Byron Murphy II takes 49ers over with 2 sacks

Seattle Seahawks defensive tackle Byron Murphy II took the San Francisco 49ers over with two sacks in the first 20 minutes of their Week 5 matchup.

The 49ers travel to face the Seahawks in their 1st meeting since last season's playoff loss

The 49ers travel to face the Seahawks in their 1st meeting since last season's playoff loss

Games between the San Francisco 49ers and Seattle Seahawks are typically intense with the two rivals often competing for NFC West supremacy

5 matchups to watch in 49ers-Seahawks: The 1 player Brock Purdy should avoid

5 matchups to watch in 49ers-Seahawks: The 1 player Brock Purdy should avoid

Highlighting 5 players to watch on the Seahawks. The 49ers should attack a couple of them.

The 49ers are running into the stingiest defense in the NFL

The 49ers are running into the stingiest defense in the NFL

Three numbers to watch heading into Week 5 between the 49ers and Seahawks

NFL predictions: Jaxon Smith-Njigba will dominate for Seahawks vs. 49ers

NFL predictions: Jaxon Smith-Njigba will dominate for Seahawks vs. 49ers

Seattle’s star could go supernova against the 49ers. Again.