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Rochester Democrat and Chronicle
Bills vs Lions prediction, keys to historic Highmark Stadium opener
The Bills officially open Highmark Stadium Thursday night in their home opener against the Lions. Here is Sal Maiorana's preview of the game.
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AP News
Bills set to open new stadium hosting the Lions in a prime-time matchup
Josh Allen is more focused on the outcome than the setting as the Buffalo Bills prepare to play the first regular-season game at their new Highmark Stadium by hosting the Detroit Lions on Thursday night
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SB Nation
Survey: Will the Lions beat the Bills in Week 2?
Checking in with Detroit Lions fans in our latest SB Nation Reacts surveys.
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SB Nation
Detroit Lions updated depth chart: Week 2 at Bills
An updated look at the 2026 Detroit Lions’ depth chart ahead of their Week 2 game vs. the Buffalo Bills.
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SB Nation
Bills news: Previewing the Lions
Points should be plentiful when Josh Allen and the Bills host Jared Goff and the Lions on Thursday Night Football.
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Bills Wire
3 potential X-factors on the Bills defense vs. Lions in Week 2
X-factors for the Bills defense against the Lions in Week 2.
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SB Nation
Detroit Lions vs. Buffalo Bills Week 2 preview: 6 key stats
A data-driven six-pack preview of Lions at Bills, focusing on key stats and matchups.
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Touchdown Wire
WATCH: Lions TE Sam LaPorta scores first TD of season
Lions tight end Sam LaPorta got his first touchdown of the season in the fourth quarter against the Bills to cut Buffalo's lead to 34-24.
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USA Today
Bills vs Lions spread predictions, odds for NFL Week 2 Thursday Night Football
The Buffalo Bills host the Detroit Lions at Highmark Stadium on Sept. 17 and USA TODAY's NFL experts have locked in their picks against the spread for the action.
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SB Nation
The Honolulu Blueprint: 4 predictions for a Lions victory over the Bills in Week 2
Predicting what the Detroit Lions will do to earn a victory over the Buffalo Bills in Week 2 of the 2026 season.
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SB Nation
5 Detroit Lions to watch at the Buffalo Bills
Can Buffalo’s defense slow down a high-powered Detroit offense?
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Sportsbook Wire
Detroit Lions at Buffalo Bills odds, picks and predictions
The Detroit Lions and the Buffalo Bills meet Thursday for their Week 2 game in Orchard Park, New York. Kickoff is scheduled for 8:15 p.m. ET.
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