Cochrane Review Questions Efficacy of Anti-Amyloid Alzheimer's Drugs
A recent analysis by the Cochrane health research organization has cast doubt on the efficacy of anti-amyloid drugs used in treating Alzheimer's disease. The review assessed 17 studies involving over 20,000 participants and concluded that these drugs, including Biogen and Eisai's Leqembi and Eli Lilly's Kisunla, likely have no clinically meaningful positive effects on cognitive function or dementia severity. The analysis also noted a small increase in the risk of brain swelling associated with these medications. Despite some drugs like Leqembi and Kisunla receiving FDA approval based on statistically significant reductions in clinical decline, the review suggests that the overall impact of amyloid-targeting therapies is minimal.