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49ers vs Cardinals asks a simple question: How big is the gap?

49ers vs Cardinals asks a simple question: How big is the gap?

The San Francisco 49ers host the Arizona Cardinals at Levi's Stadium on Sept. 27 and USA TODAY's NFL experts have locked in their picks against the spread for the action.

The 49ers dial up a hook-and-ladder play to open scoring against the Cardinals

The 49ers dial up a hook-and-ladder play to open scoring against the Cardinals

The San Francisco 49ers went deep in the playbook to open up the scoring against the Arizona Cardinals

Sportsbook Wire

Arizona Cardinals at San Francisco 49ers odds, picks and predictions

Arizona Cardinals at San Francisco 49ers odds, picks and predictions

The Arizona Cardinals and San Francisco 49ers clash in Week 2 in Santa Clara, California, at 4:05 p.m. ET.

49ers vs. Cardinals: How to watch, game time, and betting odds

49ers vs. Cardinals: How to watch, game time, and betting odds

It’s Week 3 and the Cardinals are coming to town. Here’s everything you need to know

49ers-Cardinals game thread: Can the Niners overcome all the injuries?

49ers-Cardinals game thread: Can the Niners overcome all the injuries?

The 49ers take on the Cardinals. This is our game thread.

Jordan Watkins is active for the first time this season

Jordan Watkins is active for the first time this season

Mike Evans is also active for the 49ers

Arizona Republic

Can the Arizona Cardinals upset the 49ers? Breaking down the matchup

Can the Arizona Cardinals upset the 49ers? Breaking down the matchup

The Arizona Cardinals are looking to get right against the San Francisco 49ers in Week 3, after a demoralizing blowout loss to the Seattle Seahawks.

Brock Purdy elevates his game even more to start season for the 49ers

Brock Purdy elevates his game even more to start season for the 49ers

Brock Purdy has produced at a high level ever since bursting on the scene as a seventh-round rookie in 2022 who went on a deep playoff run with the San Francisco 49ers

Arizona Cardinals defense still dealing with some injuries ahead of matchup with Niners

Arizona Cardinals defense still dealing with some injuries ahead of matchup with Niners

Check in on the Friday Cardinals injury report.

Brandin Cooks had his eye on joining the 49ers for years, GM says

Brandin Cooks had his eye on joining the 49ers for years, GM says

John Lynch said that the team and Brandin Cooks had been communicating for years before he signed with the 49ers.

George Kittle credits one key factor in 49ers' hot 2-0 start

George Kittle credits one key factor in 49ers' hot 2-0 start

The 49ers retained a lot of key offensive personnel that helped them cruise to a 2-0 record to start 2026.

49ers coach Kyle Shanahan faces another disciple in game against Cardinals coach Mike LaFleur

49ers coach Kyle Shanahan faces another disciple in game against Cardinals coach Mike LaFleur

San Francisco 49ers coach Kyle Shanahan said he might appreciate one day how many assistants that used to work under him have become head coaches in the NFL