The San Francisco 49ers are off to a strong start in 2026, but now they enter Week 5 dealing with a rash of injury issues as they gear up to face the reigning champion Seattle Seahawks.
Fullback Kyle Juszczyk, safety Marques Sigle and cornerback Upton Stout were all injured in the 49ers' Week 4 win over the Denver Broncos. With a slew of players still on injured lists or dealing with injuries that already have them ruled out for Week 5, we'll be keeping a close eye on how the 49ers injury updates come in throughout the week.
Hit refresh for all the latest injury news from San Francisco throughout Week 5 in the lead up to their game Sunday at Lumen Field vs. the Seahawks:
Nick Bosa, James Thompson Jr. likely to be ruled out
03:05 PM ET, October 7 2026, Kyle MadsonHead coach Kyle Shanahan on Monday told reporters in a press conference that
neither Bosa nor Thompson would likely return to face Seattle. Bosa is still nursing a calf injury he sustained in practice before Week 3, while Thompson is still recovering from a high ankle sprain he suffered in Week 3. Neither of them are on IR, so they could theoretically be back in Week 5, but Shanahan's lack of optimism doesn't bode well for early returns from either player.
6 49ers eligible to return from IR/PUP in Week 5
03:00 PM ET, October 7 2026, Kyle Madson- WR Christian Kirk (calf)
- OL Austen Pleasants (knee)
- LB Nick Martin (hamstring)
- CB Nate Hobbs (groin)
- DL Mykel Williams (knee)
- RB Isaac Guerendo (chest)
This article originally appeared on Niners Wire: 49ers vs. Seahawks: Every Week 5 injury update for San Francisco
