The San Francisco 49ers wrap up the final game in their three-game homestand against the Denver Broncos on Sunday.
This Week 4 matchup will be arguably the toughest test of the year for the 49ers. The toughness of their Week 1 game in Australia was mitigated some by the Los Angeles Rams' ridiculous travel plans. Then they faced a downtrodden Miami Dolphins club before welcoming in the Arizona Cardinals who are likely to finish last in the division.
Now they face a legitimate AFC Super Bowl hopeful that is coming off an impressive comeback win over the Rams. Denver also has an excellent defense that will be a real test for quarterback Brock Purdy and the 49ers' offense.
Here's where to watch Week 4:
Stream 49ers vs. Broncos
What channel is 49ers vs. Broncos on today?
- TV Channel: CBS
- Livestream: Paramount+ (free trial)
49ers vs. Broncos game time today
- Date: Sunday, Oct. 3, 2026
- Start time: 1:25 pm Pacific Time
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49ers vs. Broncos predictions, picks, odds
- Match-up prediction: Most of our expert panel likes the 49ers, but it's going to take their best game of the year. It looks like San Francisco is going to have to win via shootout with so many injuries on the defensive side. If they get into a back-and-forth game like they did against Arizona, it may be tough to continue running up points against a good Broncos defense. At some point the 49ers will turn it over and Denver will ride that momentum to a win. Broncos 27, 49ers 23
- Spread: 49ers -2.5 (-102), Broncos +2.5 (-118)
- Over/under: Over 48.5 (-108), Under 48.5 (-110)
- Moneyline: 49ers -150, Broncos +125
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This article originally appeared on Niners Wire: How to watch, stream 49ers vs. Broncos in huge Week 4 matchup
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